MIR6869

Summary

MIR6869 (microRNA 6869, HGNC:50056) is a microRNA gene on chromosome 20p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465524 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50056
Approved symbol	MIR6869
Name	microRNA 6869
Location	20p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6869
Ensembl gene	ENSG00000284436
Ensembl biotype	miRNA
Entrez	102465524
RNAcentral	URS0000759F74 — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619434

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619434 — 1 exons

Exon	Start	End
ENSE00003745822	1392900	1392961

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 68.89.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	68.89	gold quality
gastrocnemius	UBERON:0001388	52.37	gold quality
minor salivary gland	UBERON:0001830	51.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1. (PMID:32565733)
• MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus. (PMID:34007244)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.