MIR6870

Summary

MIR6870 (microRNA 6870, HGNC:50184) is a microRNA gene on chromosome 20p12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465525 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50184
Approved symbol	MIR6870
Name	microRNA 6870
Location	20p12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6870
Ensembl gene	ENSG00000273745
Ensembl biotype	miRNA
Entrez	102465525
RNAcentral	URS0000759B76 — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615931

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615931 — 1 exons

Exon	Start	End
ENSE00003715622	10649636	10649695

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 89.48.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.48	gold quality
right coronary artery	UBERON:0001625	86.14	gold quality
popliteal artery	UBERON:0002250	81.39	gold quality
tibial artery	UBERON:0007610	81.34	gold quality
bone marrow	UBERON:0002371	80.64	gold quality
descending thoracic aorta	UBERON:0002345	78.75	gold quality
ascending aorta	UBERON:0001496	78.61	gold quality
thoracic aorta	UBERON:0001515	78.39	gold quality
vagina	UBERON:0000996	78.04	gold quality
left coronary artery	UBERON:0001626	77.29	gold quality
skin of abdomen	UBERON:0001416	77.06	gold quality
placenta	UBERON:0001987	76.67	gold quality
ectocervix	UBERON:0012249	76.10	gold quality
zone of skin	UBERON:0000014	76.08	gold quality
gastrocnemius	UBERON:0001388	75.75	gold quality
blood	UBERON:0000178	75.61	gold quality
skin of leg	UBERON:0001511	75.44	gold quality
myometrium	UBERON:0001296	75.37	gold quality
left adrenal gland cortex	UBERON:0035825	74.52	gold quality
heart	UBERON:0000948	74.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.92	gold quality
endocervix	UBERON:0000458	73.39	gold quality
islet of Langerhans	UBERON:0000006	73.27	gold quality
esophagus mucosa	UBERON:0002469	73.24	gold quality
rectum	UBERON:0001052	73.11	gold quality
adipose tissue	UBERON:0001013	72.78	gold quality
heart left ventricle	UBERON:0002084	72.62	gold quality
body of uterus	UBERON:0009853	72.61	gold quality
esophagus	UBERON:0001043	72.57	gold quality
fundus of stomach	UBERON:0001160	72.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA RP11-116G8.5 promotes the progression of lung squamous cell carcinoma through sponging miR-3150b-3p/miR-6870-5p to upregulate PHF12/FOXP4. (PMID:34500373)
• MiRNA-6870-3p Regulates Lipopolysaccharide Induced Epicardial Adipose Tissue Inflammatory Genes via Targeting Tollip-Mediated JNK and NF-kappaB Signaling in Coronary Artery Disease. (PMID:36184551)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.