MIR6871

Summary

MIR6871 (microRNA 6871, HGNC:49964) is a microRNA gene on chromosome 20q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466912 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49964
Approved symbol	MIR6871
Name	microRNA 6871
Location	20q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6871
Ensembl gene	ENSG00000276169
Ensembl biotype	miRNA
Entrez	102466912
RNAcentral	URS000075F12E — miRNA, 56 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613433 — 1 exons

Exon	Start	End
ENSE00003718193	41169023	41169078

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 79.13.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.13	gold quality
fundus of stomach	UBERON:0001160	78.36	gold quality
muscle of leg	UBERON:0001383	76.15	gold quality
blood	UBERON:0000178	76.10	gold quality
gastrocnemius	UBERON:0001388	75.90	gold quality
calcaneal tendon	UBERON:0003701	75.73	gold quality
rectum	UBERON:0001052	74.14	gold quality
right adrenal gland cortex	UBERON:0035827	73.51	gold quality
corpus callosum	UBERON:0002336	71.88	gold quality
myometrium	UBERON:0001296	71.82	gold quality
heart left ventricle	UBERON:0002084	71.70	gold quality
right lobe of liver	UBERON:0001114	71.40	gold quality
islet of Langerhans	UBERON:0000006	71.34	gold quality
right lobe of thyroid gland	UBERON:0001119	71.13	gold quality
right atrium auricular region	UBERON:0006631	70.97	gold quality
heart	UBERON:0000948	70.95	gold quality
popliteal artery	UBERON:0002250	70.90	gold quality
tibial artery	UBERON:0007610	70.90	gold quality
tonsil	UBERON:0002372	70.75	gold quality
stomach	UBERON:0000945	70.72	gold quality
right adrenal gland	UBERON:0001233	70.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.60	gold quality
urinary bladder	UBERON:0001255	70.54	gold quality
endometrium	UBERON:0001295	70.50	gold quality
body of pancreas	UBERON:0001150	70.38	gold quality
body of stomach	UBERON:0001161	70.35	gold quality
ascending aorta	UBERON:0001496	70.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.20	gold quality
thoracic aorta	UBERON:0001515	70.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.