MIR6872

Summary

MIR6872 (microRNA 6872, HGNC:50037) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465526 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50037
Approved symbol	MIR6872
Name	microRNA 6872
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6872
Ensembl gene	ENSG00000283848
Ensembl biotype	miRNA
Entrez	102465526
RNAcentral	URS000075C813 — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612981

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612981 — 1 exons

Exon	Start	End
ENSE00003719540	50273236	50273297

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 76.39.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	76.39	gold quality
right atrium auricular region	UBERON:0006631	70.34	gold quality
gastrocnemius	UBERON:0001388	66.91	gold quality
heart	UBERON:0000948	65.18	gold quality
blood	UBERON:0000178	64.87	gold quality
tibial artery	UBERON:0007610	62.75	gold quality
esophagus mucosa	UBERON:0002469	54.68	gold quality
omental fat pad	UBERON:0010414	53.83	gold quality
skin of leg	UBERON:0001511	52.46	gold quality
skin of abdomen	UBERON:0001416	46.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Low mir6872 expression is associated with gastric cardia adenocarcinoma. (PMID:30656427)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.