MIR6873

Summary

MIR6873 (microRNA 6873, HGNC:50231) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466754 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50231
Approved symbol	MIR6873
Name	microRNA 6873
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6873
Ensembl gene	ENSG00000284517
Ensembl biotype	miRNA
Entrez	102466754
RNAcentral	URS000075AC29 — ncRNA, 63 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622788

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622788 — 1 exons

Exon	Start	End
ENSE00003740047	33287227	33287289

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 81.28.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.28	gold quality
adrenal gland	UBERON:0002369	74.07	gold quality
amygdala	UBERON:0001876	73.04	gold quality
blood	UBERON:0000178	72.14	gold quality
right atrium auricular region	UBERON:0006631	70.74	gold quality
adult mammalian kidney	UBERON:0000082	70.65	gold quality
stomach	UBERON:0000945	70.63	gold quality
heart left ventricle	UBERON:0002084	69.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.13	gold quality
tibial artery	UBERON:0007610	67.84	gold quality
body of stomach	UBERON:0001161	67.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.25	gold quality
transverse colon	UBERON:0001157	66.94	gold quality
skin of abdomen	UBERON:0001416	66.93	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.59	gold quality
skin of leg	UBERON:0001511	66.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.19	gold quality
body of uterus	UBERON:0009853	65.61	gold quality
right ovary	UBERON:0002118	65.56	gold quality
vagina	UBERON:0000996	65.48	gold quality
esophagus mucosa	UBERON:0002469	65.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.72	gold quality
putamen	UBERON:0001874	64.44	gold quality
left lobe of thyroid gland	UBERON:0001120	64.39	gold quality
left ovary	UBERON:0002119	63.64	gold quality
cerebellar hemisphere	UBERON:0002245	63.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.04	gold quality
minor salivary gland	UBERON:0001830	62.83	gold quality
spleen	UBERON:0002106	62.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells. (PMID:32113679)
• Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis. (PMID:34872444)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.