MIR6874

Summary

MIR6874 (microRNA 6874, HGNC:50146) is a microRNA gene on chromosome 7p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466203 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50146
Approved symbol	MIR6874
Name	microRNA 6874
Location	7p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6874
Ensembl gene	ENSG00000283419
Ensembl biotype	miRNA
Entrez	102466203
RNAcentral	URS000075C619 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635894

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635894 — 1 exons

Exon	Start	End
ENSE00003799052	5711840	5711910

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 82.70.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.70	gold quality
blood	UBERON:0000178	80.58	gold quality
monocyte	CL:0000576	78.35	gold quality
liver	UBERON:0002107	76.48	gold quality
right lobe of liver	UBERON:0001114	75.27	gold quality
stomach	UBERON:0000945	75.13	gold quality
gastrocnemius	UBERON:0001388	74.94	gold quality
corpus callosum	UBERON:0002336	72.23	gold quality
islet of Langerhans	UBERON:0000006	71.37	gold quality
Ammon’s horn	UBERON:0001954	70.78	gold quality
endocervix	UBERON:0000458	70.34	gold quality
body of stomach	UBERON:0001161	70.06	gold quality
kidney	UBERON:0002113	68.84	gold quality
tibial artery	UBERON:0007610	68.75	gold quality
popliteal artery	UBERON:0002250	68.62	gold quality
heart	UBERON:0000948	68.20	gold quality
body of uterus	UBERON:0009853	68.17	gold quality
body of pancreas	UBERON:0001150	67.56	gold quality
right atrium auricular region	UBERON:0006631	67.26	gold quality
skin of abdomen	UBERON:0001416	67.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.94	gold quality
caudate nucleus	UBERON:0001873	66.11	gold quality
putamen	UBERON:0001874	66.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.90	gold quality
thoracic aorta	UBERON:0001515	65.75	gold quality
omental fat pad	UBERON:0010414	65.63	gold quality
nucleus accumbens	UBERON:0001882	65.61	gold quality
adult mammalian kidney	UBERON:0000082	65.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.32	gold quality
transverse colon	UBERON:0001157	65.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA ODRUL regulates progression of osteosarcoma by regulating IL-6 via sponging miR-6874-3p. (PMID:35114192)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.