MIR6875

Summary

MIR6875 (microRNA 6875, HGNC:50015) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466755 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50015
Approved symbol	MIR6875
Name	microRNA 6875
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6875
Ensembl gene	ENSG00000283821
Ensembl biotype	miRNA
Entrez	102466755
RNAcentral	URS000075AB40 — ncRNA, 72 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617506

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617506 — 1 exons

Exon	Start	End
ENSE00003739715	100868036	100868107

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 72.72.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prostate gland	UBERON:0002367	72.72	gold quality
gastrocnemius	UBERON:0001388	71.75	gold quality
blood	UBERON:0000178	70.32	gold quality
right lobe of thyroid gland	UBERON:0001119	69.60	gold quality
heart left ventricle	UBERON:0002084	69.18	gold quality
right atrium auricular region	UBERON:0006631	68.99	gold quality
substantia nigra	UBERON:0002038	64.91	gold quality
liver	UBERON:0002107	64.43	gold quality
body of pancreas	UBERON:0001150	64.25	gold quality
nucleus accumbens	UBERON:0001882	63.57	gold quality
right lobe of liver	UBERON:0001114	63.38	gold quality
Ammon’s horn	UBERON:0001954	62.72	gold quality
right adrenal gland	UBERON:0001233	62.37	gold quality
left coronary artery	UBERON:0001626	61.32	gold quality
mucosa of transverse colon	UBERON:0004991	61.32	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.49	gold quality
body of uterus	UBERON:0009853	60.24	gold quality
colon	UBERON:0001155	59.64	gold quality
tibial artery	UBERON:0007610	59.49	gold quality
spleen	UBERON:0002106	59.22	gold quality
ascending aorta	UBERON:0001496	58.71	gold quality
transverse colon	UBERON:0001157	58.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.57	gold quality
upper lobe of left lung	UBERON:0008952	58.20	gold quality
lower esophagus muscularis layer	UBERON:0035833	57.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.92	gold quality
esophagus mucosa	UBERON:0002469	57.53	gold quality
lower esophagus	UBERON:0013473	57.43	gold quality
thoracic aorta	UBERON:0001515	56.65	gold quality
hypothalamus	UBERON:0001898	56.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Although further clarification is needed regarding the functions of miR-6826 and miR-6875 and their relationship to immunerelated molecules, plasma miR-6826 and miR-6875 may be useful negative biomarkers for predicting the efficacy of vaccine treatment in colorectal cancer. (PMID:27878288)
• Study provides evidence that high expression of miR-6875-3p can promote tumorigenesis of HCC in vitro and in vivo, so as to function as a novel oncogene in HCC. Authors found that miR-6875-3p plays its biological functions via the BTG2/FAK/Akt pathway. (PMID:30621734)
• Increased miR-6875-5p inhibits plasmacytoid dendritic cell differentiation via the STAT3/E2-2 pathway in recurrent spontaneous abortion. (PMID:34240166)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.