MIR6876

Summary

MIR6876 (microRNA 6876, HGNC:50181) is a microRNA gene on chromosome 8p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465527 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50181
Approved symbol	MIR6876
Name	microRNA 6876
Location	8p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6876
Ensembl gene	ENSG00000274988
Ensembl biotype	miRNA
Entrez	102465527
RNAcentral	URS000075D88B — ncRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622618

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622618 — 1 exons

Exon	Start	End
ENSE00003750556	25345402	25345474

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 80.02.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.02	gold quality
kidney	UBERON:0002113	78.38	gold quality
adrenal tissue	UBERON:0018303	77.35	gold quality
blood	UBERON:0000178	76.90	gold quality
prefrontal cortex	UBERON:0000451	75.16	gold quality
liver	UBERON:0002107	73.36	gold quality
heart left ventricle	UBERON:0002084	73.29	gold quality
adult mammalian kidney	UBERON:0000082	70.08	gold quality
heart	UBERON:0000948	69.71	gold quality
gastrocnemius	UBERON:0001388	69.61	gold quality
putamen	UBERON:0001874	69.24	gold quality
stomach	UBERON:0000945	68.99	gold quality
right lobe of liver	UBERON:0001114	68.78	gold quality
tibial artery	UBERON:0007610	68.47	gold quality
Ammon’s horn	UBERON:0001954	67.18	gold quality
thoracic aorta	UBERON:0001515	66.91	gold quality
ascending aorta	UBERON:0001496	66.89	gold quality
granulocyte	CL:0000094	66.68	gold quality
transverse colon	UBERON:0001157	66.08	gold quality
right atrium auricular region	UBERON:0006631	65.99	gold quality
body of stomach	UBERON:0001161	65.95	gold quality
minor salivary gland	UBERON:0001830	65.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.10	gold quality
amygdala	UBERON:0001876	65.06	gold quality
substantia nigra	UBERON:0002038	64.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.70	gold quality
hypothalamus	UBERON:0001898	64.68	gold quality
esophagus mucosa	UBERON:0002469	64.53	gold quality
colon	UBERON:0001155	64.49	gold quality
right frontal lobe	UBERON:0002810	64.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.02

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.