MIR6877

Summary

MIR6877 (microRNA 6877, HGNC:50205) is a microRNA gene on chromosome 9q34.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465528 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50205
Approved symbol	MIR6877
Name	microRNA 6877
Location	9q34.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6877
Ensembl gene	ENSG00000273932
Ensembl biotype	miRNA
Entrez	102465528
RNAcentral	URS00007599CF — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620452

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620452 — 1 exons

Exon	Start	End
ENSE00003737686	133051996	133052059

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 80.64.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.64	gold quality
blood	UBERON:0000178	75.90	gold quality
lower esophagus mucosa	UBERON:0035834	72.98	gold quality
body of pancreas	UBERON:0001150	72.41	gold quality
gastrocnemius	UBERON:0001388	72.30	gold quality
mucosa of transverse colon	UBERON:0004991	71.43	gold quality
left adrenal gland cortex	UBERON:0035825	71.23	gold quality
rectum	UBERON:0001052	70.40	gold quality
monocyte	CL:0000576	70.27	gold quality
heart left ventricle	UBERON:0002084	70.09	gold quality
fundus of stomach	UBERON:0001160	69.64	gold quality
right atrium auricular region	UBERON:0006631	69.58	gold quality
urinary bladder	UBERON:0001255	68.95	gold quality
body of stomach	UBERON:0001161	68.14	gold quality
gall bladder	UBERON:0002110	68.12	gold quality
tibial artery	UBERON:0007610	67.94	gold quality
right lobe of liver	UBERON:0001114	67.83	gold quality
ascending aorta	UBERON:0001496	67.73	gold quality
transverse colon	UBERON:0001157	67.63	gold quality
esophagus mucosa	UBERON:0002469	67.59	gold quality
thoracic aorta	UBERON:0001515	67.50	gold quality
left coronary artery	UBERON:0001626	67.13	gold quality
skin of abdomen	UBERON:0001416	66.94	gold quality
colon	UBERON:0001155	66.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.89	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.88	gold quality
stomach	UBERON:0000945	66.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.75	gold quality
left adrenal gland	UBERON:0001234	66.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.