MIR6878

Summary

MIR6878 (microRNA 6878, HGNC:50269) is a microRNA gene on chromosome 1q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465529 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50269
Approved symbol	MIR6878
Name	microRNA 6878
Location	1q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6878
Ensembl gene	ENSG00000283933
Ensembl biotype	miRNA
Entrez	102465529
RNAcentral	URS0000759D80 — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635784

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635784 — 1 exons

Exon	Start	End
ENSE00003792790	150492345	150492410

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 76.71.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.71	gold quality
heart left ventricle	UBERON:0002084	67.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.63	gold quality
adult mammalian kidney	UBERON:0000082	64.48	gold quality
tibial artery	UBERON:0007610	63.73	gold quality
body of stomach	UBERON:0001161	63.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.99	gold quality
omental fat pad	UBERON:0010414	57.60	gold quality
skin of abdomen	UBERON:0001416	56.03	gold quality
nucleus accumbens	UBERON:0001882	55.30	gold quality
right atrium auricular region	UBERON:0006631	50.23	gold quality
minor salivary gland	UBERON:0001830	49.04	gold quality
left lobe of thyroid gland	UBERON:0001120	48.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	46.45	gold quality
skin of leg	UBERON:0001511	45.35	gold quality
caudate nucleus	UBERON:0001873	41.89	silver quality
anterior cingulate cortex	UBERON:0009835	38.41	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.