MIR6879

Summary

MIR6879 (microRNA 6879, HGNC:49957) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466756 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49957
Approved symbol	MIR6879
Name	microRNA 6879
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6879
Ensembl gene	ENSG00000278851
Ensembl biotype	miRNA
Entrez	102466756
RNAcentral	URS000075A0C3 — ncRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610949

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610949 — 1 exons

Exon	Start	End
ENSE00003745970	65018505	65018570

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 73.90.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	73.90	gold quality
gastrocnemius	UBERON:0001388	70.85	gold quality
ascending aorta	UBERON:0001496	70.48	gold quality
right atrium auricular region	UBERON:0006631	70.45	gold quality
rectum	UBERON:0001052	70.42	gold quality
blood	UBERON:0000178	70.19	gold quality
body of pancreas	UBERON:0001150	70.17	gold quality
heart left ventricle	UBERON:0002084	69.65	gold quality
substantia nigra	UBERON:0002038	69.49	gold quality
Ammon’s horn	UBERON:0001954	68.29	gold quality
transverse colon	UBERON:0001157	67.86	gold quality
amygdala	UBERON:0001876	67.42	gold quality
body of uterus	UBERON:0009853	67.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.92	gold quality
esophagus mucosa	UBERON:0002469	65.43	gold quality
skin of abdomen	UBERON:0001416	65.35	gold quality
hypothalamus	UBERON:0001898	65.33	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.32	gold quality
minor salivary gland	UBERON:0001830	65.11	gold quality
right frontal lobe	UBERON:0002810	65.10	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.86	gold quality
left ovary	UBERON:0002119	64.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.17	gold quality
omental fat pad	UBERON:0010414	63.58	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.23	gold quality
spleen	UBERON:0002106	62.77	gold quality
skin of leg	UBERON:0001511	62.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.73	gold quality
cerebellar hemisphere	UBERON:0002245	61.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.