MIR6880

Summary

MIR6880 (microRNA 6880, HGNC:50187) is a microRNA gene on chromosome 12q24.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466204 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50187
Approved symbol	MIR6880
Name	microRNA 6880
Location	12q24.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6880
Ensembl gene	ENSG00000275967
Ensembl biotype	miRNA
Entrez	102466204
RNAcentral	URS000075C131 — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622851

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622851 — 1 exons

Exon	Start	End
ENSE00003725492	124337181	124337242

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 90.72.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	90.72	gold quality
bone marrow	UBERON:0002371	85.23	gold quality
monocyte	CL:0000576	78.60	gold quality
prefrontal cortex	UBERON:0000451	77.80	gold quality
blood	UBERON:0000178	76.67	gold quality
muscle of leg	UBERON:0001383	76.16	gold quality
gastrocnemius	UBERON:0001388	73.90	gold quality
islet of Langerhans	UBERON:0000006	72.59	gold quality
heart left ventricle	UBERON:0002084	71.93	gold quality
smooth muscle tissue	UBERON:0001135	71.78	gold quality
tonsil	UBERON:0002372	71.39	gold quality
rectum	UBERON:0001052	70.96	gold quality
heart	UBERON:0000948	70.82	gold quality
right lobe of liver	UBERON:0001114	70.68	gold quality
right atrium auricular region	UBERON:0006631	70.62	gold quality
body of stomach	UBERON:0001161	70.31	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.90	gold quality
liver	UBERON:0002107	69.82	gold quality
body of pancreas	UBERON:0001150	69.79	gold quality
stomach	UBERON:0000945	69.44	gold quality
tibial artery	UBERON:0007610	69.42	gold quality
urinary bladder	UBERON:0001255	69.24	gold quality
granulocyte	CL:0000094	68.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.01	gold quality
transverse colon	UBERON:0001157	67.95	gold quality
left adrenal gland	UBERON:0001234	67.87	gold quality
endometrium	UBERON:0001295	67.80	gold quality
amygdala	UBERON:0001876	67.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.69	gold quality
left adrenal gland cortex	UBERON:0035825	67.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.