MIR6882

Summary

MIR6882 (microRNA 6882, HGNC:49928) is a microRNA gene on chromosome 15q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465531 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49928
Approved symbol	MIR6882
Name	microRNA 6882
Location	15q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6882
Ensembl gene	ENSG00000275411
Ensembl biotype	miRNA
Entrez	102465531
RNAcentral	URS000075ACFB — ncRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619233

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619233 — 1 exons

Exon	Start	End
ENSE00003713946	74840642	74840707

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 77.88.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	77.88	gold quality
adrenal tissue	UBERON:0018303	77.08	gold quality
monocyte	CL:0000576	76.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.47	gold quality
blood	UBERON:0000178	76.31	gold quality
rectum	UBERON:0001052	74.70	gold quality
gastrocnemius	UBERON:0001388	73.68	gold quality
stomach	UBERON:0000945	71.81	gold quality
body of stomach	UBERON:0001161	70.66	gold quality
heart left ventricle	UBERON:0002084	70.22	gold quality
endometrium	UBERON:0001295	69.57	gold quality
right atrium auricular region	UBERON:0006631	68.57	gold quality
myometrium	UBERON:0001296	67.28	gold quality
right frontal lobe	UBERON:0002810	67.16	gold quality
putamen	UBERON:0001874	66.99	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.94	gold quality
granulocyte	CL:0000094	66.93	gold quality
ascending aorta	UBERON:0001496	66.77	gold quality
lower esophagus	UBERON:0013473	66.44	gold quality
transverse colon	UBERON:0001157	66.29	gold quality
omental fat pad	UBERON:0010414	66.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.86	gold quality
esophagus mucosa	UBERON:0002469	65.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.19	gold quality
body of pancreas	UBERON:0001150	65.17	gold quality
lung	UBERON:0002048	65.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.07	gold quality
left adrenal gland	UBERON:0001234	65.04	gold quality
spleen	UBERON:0002106	64.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.