MIR6883

Summary

MIR6883 (microRNA 6883, HGNC:50019) is a microRNA gene on chromosome 17p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465532 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50019
Approved symbol	MIR6883
Name	microRNA 6883
Location	17p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6883
Ensembl gene	ENSG00000284117
Ensembl biotype	miRNA
Entrez	102465532
RNAcentral	URS000075DF7D — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614952

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614952 — 1 exons

Exon	Start	End
ENSE00003742863	8144994	8145071

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 84.39.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	84.39	gold quality
duodenum	UBERON:0002114	82.88	gold quality
liver	UBERON:0002107	72.70	gold quality
blood	UBERON:0000178	70.93	gold quality
adult mammalian kidney	UBERON:0000082	68.40	gold quality
stomach	UBERON:0000945	67.21	gold quality
heart left ventricle	UBERON:0002084	65.72	gold quality
nucleus accumbens	UBERON:0001882	65.43	gold quality
caudate nucleus	UBERON:0001873	64.86	gold quality
putamen	UBERON:0001874	63.08	gold quality
hypothalamus	UBERON:0001898	59.86	gold quality
colon	UBERON:0001155	59.70	gold quality
substantia nigra	UBERON:0002038	58.71	gold quality
vermiform appendix	UBERON:0001154	57.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	57.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	52.74	gold quality
adipose tissue	UBERON:0001013	52.47	gold quality
body of pancreas	UBERON:0001150	51.56	gold quality
transverse colon	UBERON:0001157	46.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	43.82	silver quality
thoracic mammary gland	UBERON:0005200	43.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Restoring expression of miR-6883-5p and miR-149* blocked cell growth leading to G0-G1 phase cell-cycle arrest and apoptosis in colorectal cancer cells. (PMID:29061672)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.