MIR6884

Summary

MIR6884 (microRNA 6884, HGNC:50091) is a microRNA gene on chromosome 17q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466757 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50091
Approved symbol	MIR6884
Name	microRNA 6884
Location	17q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6884
Ensembl gene	ENSG00000283721
Ensembl biotype	miRNA
Entrez	102466757
RNAcentral	URS000075AC98 — ncRNA, 78 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614287

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614287 — 1 exons

Exon	Start	End
ENSE00003741642	40026332	40026409

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 83.15.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	83.15	gold quality
vermiform appendix	UBERON:0001154	79.77	gold quality
lymph node	UBERON:0000029	75.74	gold quality
muscle of leg	UBERON:0001383	72.89	gold quality
tibial artery	UBERON:0007610	69.49	gold quality
blood	UBERON:0000178	67.71	gold quality
hypothalamus	UBERON:0001898	67.63	gold quality
nucleus accumbens	UBERON:0001882	67.47	gold quality
substantia nigra	UBERON:0002038	64.73	gold quality
right atrium auricular region	UBERON:0006631	64.33	gold quality
body of stomach	UBERON:0001161	64.08	gold quality
stomach	UBERON:0000945	63.39	gold quality
body of pancreas	UBERON:0001150	59.67	gold quality
lung	UBERON:0002048	59.58	gold quality
liver	UBERON:0002107	58.85	gold quality
pituitary gland	UBERON:0000007	58.02	gold quality
gastrocnemius	UBERON:0001388	57.53	gold quality
esophagus mucosa	UBERON:0002469	55.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.26	gold quality
spleen	UBERON:0002106	55.21	gold quality
cerebral cortex	UBERON:0000956	54.10	gold quality
skin of abdomen	UBERON:0001416	51.63	gold quality
putamen	UBERON:0001874	47.64	gold quality
amygdala	UBERON:0001876	45.39	gold quality
right lobe of liver	UBERON:0001114	42.54	silver quality
anterior cingulate cortex	UBERON:0009835	42.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. (PMID:33932142)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.