MIR6886

Summary

MIR6886 (microRNA 6886, HGNC:50121) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465534 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50121
Approved symbol	MIR6886
Name	microRNA 6886
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6886
Ensembl gene	ENSG00000284553
Ensembl biotype	miRNA
Entrez	102465534
RNAcentral	URS000075A1D9 — ncRNA, 61 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619864

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619864 — 1 exons

Exon	Start	End
ENSE00003739438	11113474	11113534

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 98.47.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.47	gold quality
liver	UBERON:0002107	90.76	gold quality
adrenal tissue	UBERON:0018303	86.22	gold quality
bone marrow	UBERON:0002371	77.20	gold quality
blood	UBERON:0000178	75.94	gold quality
tibial artery	UBERON:0007610	73.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.93	gold quality
body of pancreas	UBERON:0001150	71.41	gold quality
adrenal gland	UBERON:0002369	69.64	gold quality
transverse colon	UBERON:0001157	68.55	gold quality
skin of leg	UBERON:0001511	68.09	gold quality
multicellular organism	UBERON:0000468	67.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.51	gold quality
right ovary	UBERON:0002118	66.74	gold quality
skin of abdomen	UBERON:0001416	66.63	gold quality
omental fat pad	UBERON:0010414	66.38	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.12	gold quality
esophagus mucosa	UBERON:0002469	64.89	gold quality
minor salivary gland	UBERON:0001830	64.76	gold quality
cerebellar hemisphere	UBERON:0002245	64.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.26	gold quality
left adrenal gland cortex	UBERON:0035825	63.91	gold quality
upper lobe of left lung	UBERON:0008952	63.88	gold quality
left adrenal gland	UBERON:0001234	63.48	gold quality
pituitary gland	UBERON:0000007	60.74	gold quality
left ovary	UBERON:0002119	60.50	gold quality
body of uterus	UBERON:0009853	60.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.06	gold quality
left testis	UBERON:0004533	40.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.