MIR6887

Summary

MIR6887 (microRNA 6887, HGNC:50065) is a microRNA gene on chromosome 19q13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466205 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50065
Approved symbol	MIR6887
Name	microRNA 6887
Location	19q13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6887
Ensembl gene	ENSG00000284065
Ensembl biotype	miRNA
Entrez	102466205
RNAcentral	URS000075E9EF — ncRNA, 65 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622822

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622822 — 1 exons

Exon	Start	End
ENSE00003732675	35122700	35122764

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 72.97.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	72.97	gold quality
heart left ventricle	UBERON:0002084	70.25	gold quality
tibial artery	UBERON:0007610	69.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.00	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.52	gold quality
nucleus accumbens	UBERON:0001882	65.34	gold quality
right atrium auricular region	UBERON:0006631	63.55	gold quality
caudate nucleus	UBERON:0001873	62.68	gold quality
tibial nerve	UBERON:0001323	59.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.25	gold quality
vagina	UBERON:0000996	58.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	52.10	gold quality
right frontal lobe	UBERON:0002810	45.83	gold quality
right testis	UBERON:0004534	42.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• There was a significant positive correlation between the expression of HK2P1 and HK2, and HK2P1 regulated the HK2 expression via competition for the shared miR-6887-3p. Reduced expression of HK2P1 and HK2 may have contributed to the occurrence and development of Preeclampsia. (PMID:29440331)
• Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p. (PMID:33638620)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.