MIR6888

Summary

MIR6888 (microRNA 6888, HGNC:50071) is a microRNA gene on chromosome 2q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465535 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50071
Approved symbol	MIR6888
Name	microRNA 6888
Location	2q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6888
Ensembl gene	ENSG00000275141
Ensembl biotype	miRNA
Entrez	102465535
RNAcentral	URS000075DF6E — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621977

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621977 — 1 exons

Exon	Start	End
ENSE00003742202	159186835	159186901

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 91.55.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.55	gold quality
adrenal tissue	UBERON:0018303	85.92	gold quality
bone marrow	UBERON:0002371	79.09	gold quality
gastrocnemius	UBERON:0001388	72.83	gold quality
calcaneal tendon	UBERON:0003701	72.60	gold quality
heart left ventricle	UBERON:0002084	71.93	gold quality
heart	UBERON:0000948	71.01	gold quality
endometrium	UBERON:0001295	70.97	gold quality
nucleus accumbens	UBERON:0001882	70.73	gold quality
body of stomach	UBERON:0001161	70.63	gold quality
fundus of stomach	UBERON:0001160	70.32	gold quality
adult mammalian kidney	UBERON:0000082	69.96	gold quality
body of pancreas	UBERON:0001150	69.95	gold quality
tibial artery	UBERON:0007610	68.09	gold quality
transverse colon	UBERON:0001157	67.80	gold quality
right atrium auricular region	UBERON:0006631	67.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.49	gold quality
stomach	UBERON:0000945	67.35	gold quality
ascending aorta	UBERON:0001496	67.13	gold quality
colon	UBERON:0001155	67.04	gold quality
liver	UBERON:0002107	66.70	gold quality
skin of leg	UBERON:0001511	66.58	gold quality
amygdala	UBERON:0001876	66.28	gold quality
thoracic aorta	UBERON:0001515	66.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.18	gold quality
skin of abdomen	UBERON:0001416	66.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.09	gold quality
omental fat pad	UBERON:0010414	65.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.45	gold quality
right adrenal gland cortex	UBERON:0035827	65.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.