MIR6889

Summary

MIR6889 (microRNA 6889, HGNC:50014) is a microRNA gene on chromosome 22q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466758 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50014
Approved symbol	MIR6889
Name	microRNA 6889
Location	22q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6889
Ensembl gene	ENSG00000274552
Ensembl biotype	miRNA
Entrez	102466758
RNAcentral	URS000075F059 — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613185

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613185 — 1 exons

Exon	Start	End
ENSE00003720763	41252992	41253050

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 77.56.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	77.56	gold quality
tonsil	UBERON:0002372	76.63	gold quality
monocyte	CL:0000576	76.60	gold quality
gastrocnemius	UBERON:0001388	75.46	gold quality
blood	UBERON:0000178	73.97	gold quality
islet of Langerhans	UBERON:0000006	73.33	gold quality
prefrontal cortex	UBERON:0000451	72.68	gold quality
heart left ventricle	UBERON:0002084	72.67	gold quality
heart	UBERON:0000948	72.32	gold quality
endometrium	UBERON:0001295	72.29	gold quality
right atrium auricular region	UBERON:0006631	72.00	gold quality
stomach	UBERON:0000945	71.76	gold quality
body of stomach	UBERON:0001161	71.29	gold quality
right lobe of liver	UBERON:0001114	70.91	gold quality
left adrenal gland cortex	UBERON:0035825	70.88	gold quality
rectum	UBERON:0001052	70.82	gold quality
kidney	UBERON:0002113	70.82	gold quality
body of pancreas	UBERON:0001150	70.61	gold quality
putamen	UBERON:0001874	70.60	gold quality
left adrenal gland	UBERON:0001234	70.44	gold quality
adrenal gland	UBERON:0002369	70.35	gold quality
tibial artery	UBERON:0007610	70.08	gold quality
right adrenal gland cortex	UBERON:0035827	70.01	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.66	gold quality
Ammon’s horn	UBERON:0001954	69.09	gold quality
adult mammalian kidney	UBERON:0000082	69.08	gold quality
skin of abdomen	UBERON:0001416	69.00	gold quality
transverse colon	UBERON:0001157	68.79	gold quality
zone of skin	UBERON:0000014	68.74	gold quality
esophagus mucosa	UBERON:0002469	68.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.