MIR6890

Summary

MIR6890 (microRNA 6890, HGNC:49990) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465536 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49990
Approved symbol	MIR6890
Name	microRNA 6890
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6890
Ensembl gene	ENSG00000284488
Ensembl biotype	miRNA
Entrez	102465536
RNAcentral	URS000075DE94 — ncRNA, 61 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620931

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620931 — 1 exons

Exon	Start	End
ENSE00003739103	49099854	49099914

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 84.85.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
small intestine	UBERON:0002108	84.85	gold quality
vermiform appendix	UBERON:0001154	84.57	gold quality
right atrium auricular region	UBERON:0006631	66.71	gold quality
body of pancreas	UBERON:0001150	66.25	gold quality
adrenal gland	UBERON:0002369	66.11	gold quality
omental fat pad	UBERON:0010414	65.69	gold quality
caudate nucleus	UBERON:0001873	64.79	gold quality
gastrocnemius	UBERON:0001388	64.78	gold quality
putamen	UBERON:0001874	62.80	gold quality
hypothalamus	UBERON:0001898	61.46	gold quality
tibial artery	UBERON:0007610	60.86	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.60	gold quality
esophagus mucosa	UBERON:0002469	59.79	gold quality
cerebral cortex	UBERON:0000956	58.79	gold quality
heart left ventricle	UBERON:0002084	57.52	gold quality
right frontal lobe	UBERON:0002810	55.13	gold quality
left adrenal gland	UBERON:0001234	54.30	gold quality
blood	UBERON:0000178	52.86	gold quality
substantia nigra	UBERON:0002038	43.76	gold quality
body of stomach	UBERON:0001161	42.31	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.