MIR6891

Summary

MIR6891 (microRNA 6891, HGNC:50243) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465537 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50243
Approved symbol	MIR6891
Name	microRNA 6891
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6891
Ensembl gene	ENSG00000277402
Ensembl biotype	miRNA
Entrez	102465537
RNAcentral	URS000075E69A — miRNA, 93 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618788

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618788 — 1 exons

Exon	Start	End
ENSE00003733682	31355224	31355316

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 97.74.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.74	gold quality
bone marrow	UBERON:0002371	97.09	gold quality
monocyte	CL:0000576	93.30	gold quality
apex of heart	UBERON:0002098	91.00	gold quality
blood	UBERON:0000178	90.85	gold quality
vermiform appendix	UBERON:0001154	90.49	gold quality
lower esophagus mucosa	UBERON:0035834	87.97	gold quality
spleen	UBERON:0002106	87.01	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.00	gold quality
sural nerve	UBERON:0015488	86.19	gold quality
skeletal muscle tissue	UBERON:0001134	85.74	gold quality
mucosa of transverse colon	UBERON:0004991	85.43	gold quality
upper lobe of left lung	UBERON:0008952	83.40	gold quality
left uterine tube	UBERON:0001303	82.84	gold quality
small intestine	UBERON:0002108	82.83	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.37	gold quality
skin of abdomen	UBERON:0001416	82.14	gold quality
lung	UBERON:0002048	81.56	gold quality
duodenum	UBERON:0002114	81.51	gold quality
zone of skin	UBERON:0000014	81.40	gold quality
kidney	UBERON:0002113	81.36	gold quality
adult mammalian kidney	UBERON:0000082	81.28	gold quality
islet of Langerhans	UBERON:0000006	81.20	gold quality
skin of leg	UBERON:0001511	80.81	gold quality
omental fat pad	UBERON:0010414	80.30	gold quality
adipose tissue	UBERON:0001013	80.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	79.82	gold quality
myometrium	UBERON:0001296	79.68	gold quality
transverse colon	UBERON:0001157	79.16	gold quality
intestine	UBERON:0000160	79.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• X-linked genes exhibit miR6891-5p-regulated skewing in Sjogren’s syndrome. (PMID:35538149)
• Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway. (PMID:38361148)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.