MIR6892

Summary

MIR6892 (microRNA 6892, HGNC:50053) is a microRNA gene on chromosome 7q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465538 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50053
Approved symbol	MIR6892
Name	microRNA 6892
Location	7q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6892
Ensembl gene	ENSG00000278449
Ensembl biotype	miRNA
Entrez	102465538
RNAcentral	URS000075C47A — miRNA, 115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612346 — 1 exons

Exon	Start	End
ENSE00003743883	143382686	143382800

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 79.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.7974 / max 33.9493, expressed in 1068 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81783	1.7974	1068

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.73	gold quality
blood	UBERON:0000178	78.70	gold quality
urinary bladder	UBERON:0001255	76.79	gold quality
mucosa of stomach	UBERON:0001199	76.48	gold quality
right coronary artery	UBERON:0001625	75.83	gold quality
skeletal muscle tissue	UBERON:0001134	75.51	gold quality
myometrium	UBERON:0001296	74.73	gold quality
kidney	UBERON:0002113	74.44	gold quality
descending thoracic aorta	UBERON:0002345	74.22	gold quality
islet of Langerhans	UBERON:0000006	73.84	gold quality
monocyte	CL:0000576	73.81	gold quality
sural nerve	UBERON:0015488	73.75	gold quality
liver	UBERON:0002107	72.94	gold quality
metanephros cortex	UBERON:0010533	72.44	gold quality
muscle of leg	UBERON:0001383	72.28	gold quality
lymph node	UBERON:0000029	72.12	gold quality
body of uterus	UBERON:0009853	72.12	gold quality
gastrocnemius	UBERON:0001388	71.80	gold quality
thoracic aorta	UBERON:0001515	71.24	gold quality
ascending aorta	UBERON:0001496	71.11	gold quality
ectocervix	UBERON:0012249	70.73	gold quality
body of stomach	UBERON:0001161	70.60	gold quality
right ovary	UBERON:0002118	70.54	gold quality
stomach	UBERON:0000945	70.48	gold quality
left uterine tube	UBERON:0001303	70.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.27	gold quality
lower esophagus	UBERON:0013473	70.21	gold quality
smooth muscle tissue	UBERON:0001135	70.15	gold quality
tibial artery	UBERON:0007610	70.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.