MIR6893

Summary

MIR6893 (microRNA 6893, HGNC:50130) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466271 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50130
Approved symbol	MIR6893
Name	microRNA 6893
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6893
Ensembl gene	ENSG00000276598
Ensembl biotype	miRNA
Entrez	102466271
RNAcentral	URS000075E6F3 — ncRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613458

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613458 — 1 exons

Exon	Start	End
ENSE00003723176	144435551	144435619

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 83.17.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	83.17	gold quality
adrenal tissue	UBERON:0018303	77.34	gold quality
prefrontal cortex	UBERON:0000451	75.93	gold quality
blood	UBERON:0000178	73.57	gold quality
gastrocnemius	UBERON:0001388	73.42	gold quality
fundus of stomach	UBERON:0001160	73.30	gold quality
ectocervix	UBERON:0012249	72.78	gold quality
stomach	UBERON:0000945	71.13	gold quality
heart left ventricle	UBERON:0002084	71.07	gold quality
body of stomach	UBERON:0001161	70.68	gold quality
right atrium auricular region	UBERON:0006631	70.39	gold quality
tibial artery	UBERON:0007610	68.47	gold quality
popliteal artery	UBERON:0002250	68.44	gold quality
transverse colon	UBERON:0001157	68.24	gold quality
right lobe of liver	UBERON:0001114	68.07	gold quality
left adrenal gland cortex	UBERON:0035825	67.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.68	gold quality
ascending aorta	UBERON:0001496	67.61	gold quality
body of pancreas	UBERON:0001150	67.51	gold quality
intestine	UBERON:0000160	67.41	gold quality
left adrenal gland	UBERON:0001234	67.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.84	gold quality
small intestine	UBERON:0002108	66.79	gold quality
right ovary	UBERON:0002118	66.76	gold quality
left coronary artery	UBERON:0001626	66.61	gold quality
esophagus mucosa	UBERON:0002469	66.53	gold quality
right adrenal gland	UBERON:0001233	66.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• a novel mechanism of circMTO1/miR-6893 in tumorigenesis and chemoresistance of cervical cancer, is reported. (PMID:31226633)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.