MIR6894

Summary

MIR6894 (microRNA 6894, HGNC:49938) is a microRNA gene on chromosome Xp11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466759 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49938
Approved symbol	MIR6894
Name	microRNA 6894
Location	Xp11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6894
Ensembl gene	ENSG00000277474
Ensembl biotype	miRNA
Entrez	102466759
RNAcentral	URS000075BA28 — ncRNA, 57 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622662

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622662 — 1 exons

Exon	Start	End
ENSE00003730122	53198889	53198945

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 94.38.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	94.38	gold quality
vermiform appendix	UBERON:0001154	85.97	gold quality
granulocyte	CL:0000094	84.69	gold quality
duodenum	UBERON:0002114	82.13	gold quality
calcaneal tendon	UBERON:0003701	81.88	gold quality
adrenal tissue	UBERON:0018303	80.40	gold quality
bone marrow	UBERON:0002371	79.62	gold quality
blood	UBERON:0000178	78.66	gold quality
muscle of leg	UBERON:0001383	77.05	gold quality
lymph node	UBERON:0000029	76.63	gold quality
tonsil	UBERON:0002372	76.42	gold quality
liver	UBERON:0002107	76.40	gold quality
placenta	UBERON:0001987	75.66	gold quality
gastrocnemius	UBERON:0001388	75.49	gold quality
islet of Langerhans	UBERON:0000006	74.42	gold quality
right lobe of liver	UBERON:0001114	73.64	gold quality
right adrenal gland cortex	UBERON:0035827	73.56	gold quality
heart left ventricle	UBERON:0002084	73.13	gold quality
endometrium	UBERON:0001295	72.67	gold quality
rectum	UBERON:0001052	72.55	gold quality
heart	UBERON:0000948	72.05	gold quality
myometrium	UBERON:0001296	71.91	gold quality
left adrenal gland cortex	UBERON:0035825	71.91	gold quality
adrenal gland	UBERON:0002369	71.49	gold quality
kidney	UBERON:0002113	71.44	gold quality
body of pancreas	UBERON:0001150	71.12	gold quality
stomach	UBERON:0000945	70.97	gold quality
right atrium auricular region	UBERON:0006631	70.84	gold quality
body of stomach	UBERON:0001161	70.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.