MIR6895

Summary

MIR6895 (microRNA 6895, HGNC:50210) is a microRNA gene on chromosome Xp11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465539 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50210
Approved symbol	MIR6895
Name	microRNA 6895
Location	Xp11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6895
Ensembl gene	ENSG00000276575
Ensembl biotype	miRNA
Entrez	102465539
RNAcentral	URS000075A7CA — ncRNA, 78 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613497

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613497 — 1 exons

Exon	Start	End
ENSE00003741930	53195411	53195488

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 84.64.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	84.64	gold quality
duodenum	UBERON:0002114	83.81	gold quality
adrenal tissue	UBERON:0018303	82.92	gold quality
bone marrow	UBERON:0002371	81.02	gold quality
lower esophagus mucosa	UBERON:0035834	80.93	gold quality
blood	UBERON:0000178	78.41	gold quality
endometrium	UBERON:0001295	77.78	gold quality
granulocyte	CL:0000094	77.73	gold quality
tonsil	UBERON:0002372	76.84	gold quality
smooth muscle tissue	UBERON:0001135	76.33	gold quality
lymph node	UBERON:0000029	76.18	gold quality
monocyte	CL:0000576	76.02	gold quality
calcaneal tendon	UBERON:0003701	75.23	gold quality
muscle of leg	UBERON:0001383	74.89	gold quality
placenta	UBERON:0001987	74.43	gold quality
gastrocnemius	UBERON:0001388	74.20	gold quality
descending thoracic aorta	UBERON:0002345	74.20	gold quality
prefrontal cortex	UBERON:0000451	74.11	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.68	gold quality
vagina	UBERON:0000996	73.36	gold quality
metanephros cortex	UBERON:0010533	73.16	gold quality
stomach	UBERON:0000945	72.93	gold quality
body of uterus	UBERON:0009853	72.72	gold quality
myometrium	UBERON:0001296	72.67	gold quality
heart left ventricle	UBERON:0002084	72.49	gold quality
right ovary	UBERON:0002118	72.45	gold quality
esophagus mucosa	UBERON:0002469	72.31	gold quality
rectum	UBERON:0001052	72.30	gold quality
adrenal gland	UBERON:0002369	72.25	gold quality
saliva-secreting gland	UBERON:0001044	72.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.