MIR7-1

Summary

MIR7-1 (microRNA 7-1, HGNC:31638) is a microRNA gene on chromosome 9q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407043 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31638
Approved symbol	MIR7-1
Name	microRNA 7-1
Location	9q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7-1
Ensembl gene	ENSG00000284179
Ensembl biotype	miRNA
OMIM	615239
Entrez	407043
RNAcentral	URS00002C5007 — miRNA, 110 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384871

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384871 — 1 exons

Exon	Start	End
ENSE00001499878	83969748	83969857

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 80.90.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	80.90	gold quality
adult mammalian kidney	UBERON:0000082	77.66	gold quality
blood	UBERON:0000178	77.62	gold quality
adrenal gland	UBERON:0002369	75.59	gold quality
liver	UBERON:0002107	73.74	gold quality
left lobe of thyroid gland	UBERON:0001120	71.05	gold quality
tibial artery	UBERON:0007610	70.49	gold quality
adipose tissue	UBERON:0001013	70.08	gold quality
body of pancreas	UBERON:0001150	69.03	gold quality
omental fat pad	UBERON:0010414	67.96	gold quality
islet of Langerhans	UBERON:0000006	67.42	gold quality
anterior cingulate cortex	UBERON:0009835	67.32	gold quality
muscle of leg	UBERON:0001383	65.15	gold quality
gastrocnemius	UBERON:0001388	65.01	gold quality
stomach	UBERON:0000945	63.76	gold quality
putamen	UBERON:0001874	62.42	gold quality
esophagus mucosa	UBERON:0002469	62.28	gold quality
body of stomach	UBERON:0001161	61.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.59	gold quality
heart	UBERON:0000948	59.11	gold quality
Ammon’s horn	UBERON:0001954	58.53	gold quality
heart left ventricle	UBERON:0002084	57.30	gold quality
prostate gland	UBERON:0002367	51.44	gold quality
caudate nucleus	UBERON:0001873	47.44	gold quality
hypothalamus	UBERON:0001898	45.58	gold quality
left testis	UBERON:0004533	24.76	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-7 is the most abundant endocrine miRNA in islets while miR-375 is the most abundant intra-islet miRNA. (PMID:18086561)
• microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways (PMID:18483236)
• Pak1 is a target of miR-7 and that HoxD10 plays a regulatory role in modifying the expression of miR-7. (PMID:18922890)
• The specific localization of miR-7 expression to fetal and adult endocrine cells indicates a potential role for miR-7 in endocrine cell differentiation and/or function. (PMID:19135553)
• miR-7 plays an important role in radioresistance of nasopharyngeal carcinoma cells to X-rays. (PMID:20813671)
• Results demonstrated that miR-7 regulates the IGF1R/Akt signalling pathway by post-transcriptional regulation of IGF1R. (PMID:20819078)
• this study demonstrates that host genetic variants could disturb the regulation of the let-7/LIN28 double-negative feedback loop and alter breast cancer risk. (PMID:21912531)
• MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. (PMID:22614005)
• analysis of regulation of pancreatic microRNA-7 expression (PMID:22675342)
• the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. (PMID:22705304)
• A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3’-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. (PMID:22768238)
• MiR-7 transfection into ovarian cancer cells induces changes in cell adhesion and other developmental networks, while miR-128 transfection induces changes in cell cycle control. (PMID:22853714)
• Data show that miR-7 inhibits the effects of TLR9 signaling on lung cancer cells through regulation of the PIK3R3/Akt pathway. (PMID:23135998)
• Overexpression of miR-7-1 increases efficacy of green tea polyphenols leading to induction of apoptosis in malignant neuroblastoma cells. (PMID:23192662)
• miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling. (PMID:23206698)
• Data suggest that miR-7 acts as a brake on adult pancreatic beta-cell proliferation; thus, miR-7 could be a therapeutic target for diabetes. (PMID:23223022)
• findings show MiR-7 variation is not associated with Parkinson’s disease in Chinese patients (PMID:23281385)
• Loss of microRNA-7 expression is associated with alignant glioma. (PMID:23373996)
• Results suggest that miR-7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer. (PMID:23384942)
• MiR-141, miR-429 and miR-7-1-3p were significantly increased in seminal plasma of patients with non-obstructive azoospermia. (PMID:23559187)
• miR-7 was up-regulated in RCC and it played an important role in RCC by affecting cellular migration, proliferation and apoptosis. (PMID:23793934)
• The altered dynamics of CD44 in the cell membrane demonstrated a further action of miR-7 in regulating the hyaluronic acid-dependent CD44/EGFR pathway. (PMID:24134702)
• Levels of PAX6 were increased, while the expression of miR-7 was reduced with malignancy of colorectal cancer. PAX6 was identified as a target of miR-7, and its expression was negatively regulated by miR-7 in human colorectal cancer cells. (PMID:24185687)
• miR-7 exerts tumor-suppressive effects in hepatocarcinogenesis through the suppression of oncogene CCNE1 expression. (PMID:24370822)
• This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. (PMID:24412053)
• expression of miR-7 significantly suppressed EGFR expression at both the mRNA and protein levels (PMID:24573489)
• Study shows that microRNA-7 (miR-7) is a common regulator of the phosphoinositide-3-kinase (PI3K)/ATK and Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways, both of which are launched by EGFR through its two direct targets, the transcription factors PI3K and Raf-1, respectively. (PMID:24603851)
• Our results suggest that miR-7 and miR-221 peripheral whole-blood expression levels can be potential predictive biomarkers of CRPC development (PMID:24760272)
• results reveal an interconnecting miR-7 genomic circuit that regulates insulin granule exocytosis in pancreatic beta cells and support a role for miR-7 in the adaptation of pancreatic beta cell function in obesity and type 2 diabetes (PMID:24789908)
• miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in epithelial ovarian cancer cell lines (PMID:24816687)
• Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury. (PMID:24925797)
• Our data may suggest that the downregulation of pulmonary Epac1 expression in COPD patients is related to the upregulation of miRNA-7 (PMID:24994109)
• These data suggest that miR-7-5p functions as a tumor suppressor gene to regulate glioblastoma microvascular endothelial cell proliferation potentially by targeting the RAF1 oncogene (PMID:25027403)
• miR-7 acts as an oncomiR in the epithelial cellular context, where through the negative regulation of KLF4-dependent signaling pathways, miR-7 promotes cellular transformation and tumor growth. (PMID:25181544)
• In pancreatic cancer cells curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7. (PMID:25256401)
• miR-7 inhibits cellular growth and glucose metabolism in gliomas, at least partially, by regulating the IGF-1R/Akt signaling pathway. (PMID:25394492)
• Our data indicate that miR-7-5p has a critical function through blocking REGgamma in breast cancer cells. (PMID:25511742)
• miR-7 regulated pathways, including EGFR and Src kinase, represent targets for the therapeutic intervention of refractory and metastatic HER2Delta16 driven breast cancer (PMID:25532106)
• microRNA-7, by down-regulating RelA, augments Glut3 expression, promotes glycolysis, and subsequently prevents MPP(+)-induced cell death (PMID:25814668)
• Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems to be a possible miR-7 target in OC. (PMID:25862909)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-7ba	ENSDARG00000081109
mus_musculus	Mir7-1	ENSMUSG00000065434
rattus_norvegicus	Mir7-1	ENSRNOG00000035613
drosophila_melanogaster	mir-7	FBGN0262370

Paralogs (1): MIR7-3 (ENSG00000207630)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.