MIR7-2

Summary

MIR7-2 (microRNA 7-2, HGNC:31639) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407044 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31639
Approved symbol	MIR7-2
Name	microRNA 7-2
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7-2
Ensembl gene	ENSG00000207703
Ensembl biotype	miRNA
OMIM	620898
Entrez	407044
RNAcentral	URS000075CAE5 — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384970

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384970 — 1 exons

Exon	Start	End
ENSE00001499977	88611825	88611934

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 83.71.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	83.71	gold quality
blood	UBERON:0000178	79.10	gold quality
tibial artery	UBERON:0007610	70.87	gold quality
Ammon’s horn	UBERON:0001954	70.82	gold quality
omental fat pad	UBERON:0010414	69.15	gold quality
adrenal tissue	UBERON:0018303	69.15	gold quality
esophagus mucosa	UBERON:0002469	66.82	gold quality
right ovary	UBERON:0002118	66.55	gold quality
lung	UBERON:0002048	64.70	gold quality
spleen	UBERON:0002106	64.70	gold quality
thyroid gland	UBERON:0002046	63.89	gold quality
left lobe of thyroid gland	UBERON:0001120	63.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.41	gold quality
pituitary gland	UBERON:0000007	63.24	gold quality
anterior cingulate cortex	UBERON:0009835	60.94	gold quality
cerebellar hemisphere	UBERON:0002245	60.51	gold quality
right lobe of thyroid gland	UBERON:0001119	58.46	gold quality
corpus callosum	UBERON:0002336	45.27	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The specific localization of miR-7 expression to fetal and adult endocrine cells indicates a potential role for miR-7 in endocrine cell differentiation and/or function. (PMID:19135553)
• A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3’-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. (PMID:22768238)
• MiR-7 transfection into ovarian cancer cells induces changes in cell adhesion and other developmental networks, while miR-128 transfection induces changes in cell cycle control. (PMID:22853714)
• Data show that miR-7 inhibits the effects of TLR9 signaling on lung cancer cells through regulation of the PIK3R3/Akt pathway. (PMID:23135998)
• miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling. (PMID:23206698)
• findings show MiR-7 variation is not associated with Parkinson’s disease in Chinese patients (PMID:23281385)
• miR-7 was up-regulated in RCC and it played an important role in RCC by affecting cellular migration, proliferation and apoptosis. (PMID:23793934)
• This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. (PMID:24412053)
• expression of miR-7 significantly suppressed EGFR expression at both the mRNA and protein levels (PMID:24573489)
• Study shows that microRNA-7 (miR-7) is a common regulator of the phosphoinositide-3-kinase (PI3K)/ATK and Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways, both of which are launched by EGFR through its two direct targets, the transcription factors PI3K and Raf-1, respectively. (PMID:24603851)
• These data suggest that miR-7-5p functions as a tumor suppressor gene to regulate glioblastoma microvascular endothelial cell proliferation potentially by targeting the RAF1 oncogene (PMID:25027403)
• In pancreatic cancer cells curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7. (PMID:25256401)
• miR-7 inhibits cellular growth and glucose metabolism in gliomas, at least partially, by regulating the IGF-1R/Akt signaling pathway. (PMID:25394492)
• Our data indicate that miR-7-5p has a critical function through blocking REGgamma in breast cancer cells. (PMID:25511742)
• microRNA-7, by down-regulating RelA, augments Glut3 expression, promotes glycolysis, and subsequently prevents MPP(+)-induced cell death (PMID:25814668)
• microRNA-7 can differentiate human induced pluripotent stem cells into functional isletlike cell clusters in a short time. (PMID:26103160)
• data suggested that miR-7 mediated small cell lung cancer chemoresistance by repressing MRP1/ABCC1 (PMID:26108539)
• MicroRNA-7 has a role in inhibiting the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway (PMID:26172296)
• These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway. (PMID:26453926)
• The expanding role of miR-7 in the context of health, with emphasis on organ differentiation and development. [review] (PMID:26546742)
• Study demonstrated that miR-let-7b or exosomes containing miR-let-7b could transform the RA and/or mouse naive or antiinflammatory macrophages into inflammatory M1 macrophages via TLR-7 ligation. miR-let-7b provokes arthritis by remodeling naive myeloid cells into M1 macrophages via TLR-7 ligation, since joint swelling and M1 macrophages are absent in TLR-7-deficient mice. (PMID:26662519)
• Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma (PMID:26831666)
• STAT1 binding sites were identified on the putative miR-7 promoter and stimulation of fibroblasts with the inflammatory cytokine, interferon-gamma (IFN-gamma), significantly increased miR-7 transcriptional activity and resulted in upregulated miR-7 and loss of EGFR. (PMID:26931423)
• miRNA-7-5p can regulate the expression of human alveolar ENaC by targeting the mTORC2/SGK-1 signaling pathway. (PMID:27331901)
• miR-7-KLF4-VEGF signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells , suggesting that miR-7 is a potential agent for the development of anti-angiogenic therapeutics in vascular diseases and solid tumors (PMID:27431648)
• TWEAK-stimulated macrophages inhibit the metastasis of EOC cells via shuttling of exosomal miR-7 to epithelial ovarian cancer cells, thereby inhibiting the EGFR/AKT/ERK1/2 pathway. (PMID:28216373)
• miR-7 might be a promising prognostic marker and therapeutic target in esophageal squamous cell carcinoma; Low expression levels of miR-7 were associated with poor prognosis (PMID:28314263)
• miR-7 might function as an important regulator to impair autophagy-derived pools of glucose to suppress pancreatic cancer progress. (PMID:28450156)
• The miRNA miR-7-5p may be a promising biomarker test for neuroendocrine neoplasms of the small intestine (PMID:28848144)
• MiR-7 was upregulated in MCF-10A cells by hepatocyte growth factor (HGF), and subsequently downregulated upon treatment with siRNA against HGF. HGF expression did not significantly change through either an upregulation or downregulation of miR-7 expression, suggesting that HGF acts upstream of miR-7. Results indicate that miR-7 mediates the activity of HGF to suppress oncogenic proteins. (PMID:29133945)
• miR-7 may act as novel prognostic biomarker and potential therapeutic target for aberrant NF-kappaB-driven gastric cancer distant metastasis. (PMID:30728051)
• Colorectal cancer tissues showed increased microvascular density and EGFR expression, activated ERK signaling, and miR-7 downregulation. EGFR was a target gene of miR-7. miR-7 overexpression and EGFR silencing decreased vasculogenic mimicry density, cell migration, and cell invasion, but increased cell apoptosis. (PMID:30909065)
• miR-7 represses the initiation and progression of osteosarcoma cells through the inhibition of IGF1R. (PMID:31102265)
• miR-7-5p targets PARP1 to exert its suppressive effects on homologous recombination repair, indicating that the alteration of the expression of miR-7-5p may be a promising strategy for overcoming chemo-resistance in SCLC therapy. (PMID:31215481)
• Effect of miR-7 on resistance of breast cancer cells to adriamycin via regulating EGFR/PI3K signaling pathway. (PMID:31298380)
• miR-7 inhibition protects human osteoblasts from Dexamethasone via activation of EGFR signaling. (PMID:31313024)
• identified both miR-7-5p and miR-141-3p as mediators of transferrin receptor (TfR1) mRNA degradation during iron-repletion. (PMID:31439810)
• Down-regulation and clinical significance of miR-7-2-3p in papillary thyroid carcinoma (PMID:31538956)
• High-throughput screening identified miR-7-2-3p and miR-29c-3p as metastasis suppressors in gallbladder carcinoma. (PMID:31562534)
• MicroRNA-7 promotes neural differentiation of trabecular meshwork mesenchymal stem cell on nanofibrous scaffold. (PMID:31692062)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.