MIR7-3

Summary

MIR7-3 (microRNA 7-3, HGNC:31640) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407045 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31640
Approved symbol	MIR7-3
Name	microRNA 7-3
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7-3
Ensembl gene	ENSG00000207630
Ensembl biotype	miRNA
Entrez	407045
RNAcentral	URS00004C38BB — miRNA, 110 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384898

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384898 — 1 exons

Exon	Start	End
ENSE00001499905	4770670	4770779

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 76.45.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	76.45	gold quality
lung	UBERON:0002048	75.11	gold quality
gastrocnemius	UBERON:0001388	73.34	gold quality
pituitary gland	UBERON:0000007	71.70	gold quality
blood	UBERON:0000178	71.28	gold quality
body of pancreas	UBERON:0001150	70.34	gold quality
anterior cingulate cortex	UBERON:0009835	69.28	gold quality
left adrenal gland	UBERON:0001234	69.02	gold quality
transverse colon	UBERON:0001157	68.26	gold quality
hypothalamus	UBERON:0001898	68.24	gold quality
amygdala	UBERON:0001876	67.82	gold quality
esophagus mucosa	UBERON:0002469	67.81	gold quality
heart left ventricle	UBERON:0002084	67.60	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.60	gold quality
adenohypophysis	UBERON:0002196	67.59	gold quality
right frontal lobe	UBERON:0002810	67.46	gold quality
cerebellar hemisphere	UBERON:0002245	67.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.91	gold quality
omental fat pad	UBERON:0010414	66.83	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.61	gold quality
Ammon’s horn	UBERON:0001954	66.24	gold quality
skin of leg	UBERON:0001511	66.21	gold quality
skin of abdomen	UBERON:0001416	65.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.92	gold quality
urinary bladder	UBERON:0001255	65.89	gold quality
spleen	UBERON:0002106	65.10	gold quality
prostate gland	UBERON:0002367	64.87	gold quality
vagina	UBERON:0000996	64.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The specific localization of miR-7 expression to fetal and adult endocrine cells indicates a potential role for miR-7 in endocrine cell differentiation and/or function. (PMID:19135553)
• A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3’-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. (PMID:22768238)
• MiR-7 transfection into ovarian cancer cells induces changes in cell adhesion and other developmental networks, while miR-128 transfection induces changes in cell cycle control. (PMID:22853714)
• Data show that miR-7 inhibits the effects of TLR9 signaling on lung cancer cells through regulation of the PIK3R3/Akt pathway. (PMID:23135998)
• miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling. (PMID:23206698)
• findings show MiR-7 variation is not associated with Parkinson’s disease in Chinese patients (PMID:23281385)
• miR-7 was up-regulated in RCC and it played an important role in RCC by affecting cellular migration, proliferation and apoptosis. (PMID:23793934)
• This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. (PMID:24412053)
• expression of miR-7 significantly suppressed EGFR expression at both the mRNA and protein levels (PMID:24573489)
• Study shows that microRNA-7 (miR-7) is a common regulator of the phosphoinositide-3-kinase (PI3K)/ATK and Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways, both of which are launched by EGFR through its two direct targets, the transcription factors PI3K and Raf-1, respectively. (PMID:24603851)
• These data suggest that miR-7-5p functions as a tumor suppressor gene to regulate glioblastoma microvascular endothelial cell proliferation potentially by targeting the RAF1 oncogene (PMID:25027403)
• In pancreatic cancer cells curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7. (PMID:25256401)
• miR-7 inhibits cellular growth and glucose metabolism in gliomas, at least partially, by regulating the IGF-1R/Akt signaling pathway. (PMID:25394492)
• Our data indicate that miR-7-5p has a critical function through blocking REGgamma in breast cancer cells. (PMID:25511742)
• microRNA-7, by down-regulating RelA, augments Glut3 expression, promotes glycolysis, and subsequently prevents MPP(+)-induced cell death (PMID:25814668)
• microRNA-7 can differentiate human induced pluripotent stem cells into functional isletlike cell clusters in a short time. (PMID:26103160)
• data suggested that miR-7 mediated small cell lung cancer chemoresistance by repressing MRP1/ABCC1 (PMID:26108539)
• MicroRNA-7 has a role in inhibiting the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway (PMID:26172296)
• These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway. (PMID:26453926)
• The expanding role of miR-7 in the context of health, with emphasis on organ differentiation and development. [review] (PMID:26546742)
• Study demonstrated that miR-let-7b or exosomes containing miR-let-7b could transform the RA and/or mouse naive or antiinflammatory macrophages into inflammatory M1 macrophages via TLR-7 ligation. miR-let-7b provokes arthritis by remodeling naive myeloid cells into M1 macrophages via TLR-7 ligation, since joint swelling and M1 macrophages are absent in TLR-7-deficient mice. (PMID:26662519)
• Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma (PMID:26831666)
• STAT1 binding sites were identified on the putative miR-7 promoter and stimulation of fibroblasts with the inflammatory cytokine, interferon-gamma (IFN-gamma), significantly increased miR-7 transcriptional activity and resulted in upregulated miR-7 and loss of EGFR. (PMID:26931423)
• miRNA-7-5p can regulate the expression of human alveolar ENaC by targeting the mTORC2/SGK-1 signaling pathway (PMID:27331901)
• miR-7-KLF4-VEGF signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells , suggesting that miR-7 is a potential agent for the development of anti-angiogenic therapeutics in vascular diseases and solid tumors (PMID:27431648)
• TWEAK-stimulated macrophages inhibit the metastasis of EOC cells via shuttling of exosomal miR-7 to epithelial ovarian cancer cells, thereby inhibiting the EGFR/AKT/ERK1/2 pathway. (PMID:28216373)
• miR-7 might function as an important regulator to impair autophagy-derived pools of glucose to suppress pancreatic cancer progress. (PMID:28450156)
• Integrative miRNA analysis identified Hsa-miR-3754 and hsa-miR-7-3 significantly associated with shortened survival time and more death cases of patients with cervical neoplasm. These miRNA are potential prognostic targets for cervical cancer (PMID:28771797)
• The miRNA miR-7-5p may be a promising biomarker test for neuroendocrine neoplasms of the small intestine (PMID:28848144)
• MiR-7 was upregulated in MCF-10A cells by hepatocyte growth factor (HGF), and subsequently downregulated upon treatment with siRNA against HGF. HGF expression did not significantly change through either an upregulation or downregulation of miR-7 expression, suggesting that HGF acts upstream of miR-7. Results indicate that miR-7 mediates the activity of HGF to suppress oncogenic proteins. (PMID:29133945)
• miR-7 may act as novel prognostic biomarker and potential therapeutic target for aberrant NF-kappaB-driven gastric cancer distant metastasis. (PMID:30728051)
• Colorectal cancer tissues showed increased microvascular density and EGFR expression, activated ERK signaling, and miR-7 downregulation. EGFR was a target gene of miR-7. miR-7 overexpression and EGFR silencing decreased vasculogenic mimicry density, cell migration, and cell invasion, but increased cell apoptosis. (PMID:30909065)
• miR-7 represses the initiation and progression of osteosarcoma cells through the inhibition of IGF1R. (PMID:31102265)
• miR-7-5p targets PARP1 to exert its suppressive effects on homologous recombination repair, indicating that the alteration of the expression of miR-7-5p may be a promising strategy for overcoming chemo-resistance in SCLC therapy. (PMID:31215481)
• Effect of miR-7 on resistance of breast cancer cells to adriamycin via regulating EGFR/PI3K signaling pathway. (PMID:31298380)
• miR-7 inhibition protects human osteoblasts from Dexamethasone via activation of EGFR signaling. (PMID:31313024)
• identified both miR-7-5p and miR-141-3p as mediators of transferrin receptor (TfR1) mRNA degradation during iron-repletion (PMID:31439810)
• MicroRNA-7 promotes neural differentiation of trabecular meshwork mesenchymal stem cell on nanofibrous scaffold. (PMID:31692062)
• MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer. (PMID:32566037)
• MicroRNA-7 targets T-Box 2 to inhibit epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme. (PMID:32861705)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir7a-3	ENSDARG00000081629
rattus_norvegicus	Mir9	ENSRNOG00000049078
drosophila_melanogaster	mir-7	FBGN0262370

Paralogs (1): MIR7-1 (ENSG00000284179)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.