MIR7-3HG

Summary

MIR7-3HG (MIR7-3 host gene, HGNC:30049) is a long non-coding RNA gene on chromosome 19p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30049
Approved symbol	MIR7-3HG
Name	MIR7-3 host gene
Location	19p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PGSF1, PGSF1a, PGSF1b, Huh7, uc002mbe.2
Ensembl gene	ENSG00000176840
Ensembl biotype	lncRNA
Entrez	284424
RNAcentral	URS000075D132 — lncRNA, 768 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 84 — 84 lncRNA

ENST00000317292, ENST00000586721, ENST00000588711, ENST00000588758, ENST00000588923, ENST00000589368, ENST00000589639, ENST00000591008, ENST00000592663, ENST00000592709, ENST00000653012, ENST00000653316, ENST00000653355, ENST00000653646, ENST00000654084, ENST00000654534, ENST00000655163, ENST00000655375, ENST00000655494, ENST00000656089, ENST00000656469, ENST00000657100, ENST00000657474, ENST00000658545, ENST00000658818, ENST00000660172, ENST00000660889, ENST00000660973, ENST00000661584, ENST00000662608, ENST00000662725, ENST00000663010, ENST00000663176, ENST00000663804, ENST00000664951, ENST00000665092, ENST00000666056, ENST00000666837, ENST00000666978, ENST00000667215, ENST00000667223, ENST00000667444, ENST00000668602, ENST00000669248, ENST00000669408, ENST00000669700, ENST00000669889, ENST00000670131, ENST00000670508, ENST00000684819, ENST00000688490, ENST00000691766, ENST00000702540, ENST00000702630, ENST00000702698, ENST00000702816, ENST00000767162, ENST00000767163, ENST00000767164, ENST00000767165, ENST00000767166, ENST00000767167, ENST00000767168, ENST00000767169, ENST00000767170, ENST00000767171, ENST00000767172, ENST00000767173, ENST00000767174, ENST00000767175, ENST00000767176, ENST00000767177, ENST00000767178, ENST00000767179, ENST00000767180, ENST00000767181, ENST00000767182, ENST00000767183, ENST00000767184, ENST00000767185, ENST00000767186, ENST00000767187, ENST00000767188, ENST00000767189

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000317292 — 3 exons

Exon	Start	End
ENSE00003571843	4769630	4769757
ENSE00004126455	4772164	4772588
ENSE00004126479	4769127	4769351

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 99.43.

FANTOM5 (CAGE): breadth broad, TPM avg 11.1334 / max 3953.1063, expressed in 243 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173370	11.1334	243

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pituitary gland	UBERON:0000007	99.43	gold quality
adenohypophysis	UBERON:0002196	99.13	gold quality
islet of Langerhans	UBERON:0000006	97.25	gold quality
sperm	CL:0000019	89.29	silver quality
right frontal lobe	UBERON:0002810	88.27	gold quality
anterior cingulate cortex	UBERON:0009835	88.21	gold quality
hypothalamus	UBERON:0001898	86.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.64	gold quality
Ammon’s horn	UBERON:0001954	85.63	gold quality
prefrontal cortex	UBERON:0000451	85.25	gold quality
amygdala	UBERON:0001876	85.03	gold quality
pancreas	UBERON:0001264	84.71	gold quality
neocortex	UBERON:0001950	84.35	gold quality
frontal cortex	UBERON:0001870	84.26	gold quality
middle temporal gyrus	UBERON:0002771	84.16	gold quality
cerebellar hemisphere	UBERON:0002245	83.89	gold quality
cerebellar cortex	UBERON:0002129	83.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.68	gold quality
cerebral cortex	UBERON:0000956	83.63	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.39	gold quality
forebrain	UBERON:0001890	82.34	gold quality
cerebellum	UBERON:0002037	82.13	gold quality
brain	UBERON:0000955	80.88	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.75	silver quality
Brodmann (1909) area 23	UBERON:0013554	80.56	gold quality
body of pancreas	UBERON:0001150	80.40	gold quality
right testis	UBERON:0004534	80.28	gold quality
primary visual cortex	UBERON:0002436	80.22	gold quality
left testis	UBERON:0004533	80.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway. (PMID:26453926)
• Our study suggested that miR-7 suppressed the expression of VDAC1 in hepatocellular carcinoma (PMID:26831666)
• miR-7-KLF4-VEGF signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells , suggesting that miR-7 is a potential agent for the development of anti-angiogenic therapeutics in vascular diseases and solid tumors (PMID:27431648)
• These data suggest a new and interesting role of MIR7-3HG as an anti-autophagic MIRNA that may affect oncogenesis through the regulation of the tumor suppressor AMBRA1. (PMID:28059583)
• A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic beta-cells through the PI3K/AKT signaling pathway. (PMID:36731335)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.