MIR7106

Summary

MIR7106 (microRNA 7106, HGNC:50085) is a microRNA gene on chromosome 12q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466222 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50085
Approved symbol	MIR7106
Name	microRNA 7106
Location	12q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7106
Ensembl gene	ENSG00000276908
Ensembl biotype	miRNA
Entrez	102466222
RNAcentral	URS000075EBFD — ncRNA, 65 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612419

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612419 — 1 exons

Exon	Start	End
ENSE00003747972	113159113	113159177

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 71.66.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	71.66	gold quality
blood	UBERON:0000178	68.80	gold quality
heart left ventricle	UBERON:0002084	67.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.31	gold quality
anterior cingulate cortex	UBERON:0009835	64.17	gold quality
lung	UBERON:0002048	63.12	gold quality
putamen	UBERON:0001874	62.96	gold quality
right lobe of liver	UBERON:0001114	62.57	gold quality
left ovary	UBERON:0002119	62.51	gold quality
omental fat pad	UBERON:0010414	62.40	gold quality
right frontal lobe	UBERON:0002810	61.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.29	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.26	gold quality
minor salivary gland	UBERON:0001830	61.25	gold quality
cerebellar hemisphere	UBERON:0002245	61.20	gold quality
transverse colon	UBERON:0001157	60.94	gold quality
left adrenal gland	UBERON:0001234	60.88	gold quality
right ovary	UBERON:0002118	60.56	gold quality
ascending aorta	UBERON:0001496	60.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.46	gold quality
thoracic mammary gland	UBERON:0005200	58.54	gold quality
body of stomach	UBERON:0001161	57.93	gold quality
skin of abdomen	UBERON:0001416	57.87	gold quality
vagina	UBERON:0000996	57.69	gold quality
spleen	UBERON:0002106	57.23	gold quality
upper lobe of left lung	UBERON:0008952	56.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.48	gold quality
pituitary gland	UBERON:0000007	55.16	gold quality
lymph node	UBERON:0000029	53.42	gold quality
left lobe of thyroid gland	UBERON:0001120	53.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.