MIR7108

Summary

MIR7108 (microRNA 7108, HGNC:49998) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466806 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49998
Approved symbol	MIR7108
Name	microRNA 7108
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7108
Ensembl gene	ENSG00000283728
Ensembl biotype	miRNA
Entrez	102466806
RNAcentral	URS000075B9C6 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614319

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614319 — 1 exons

Exon	Start	End
ENSE00003714155	2434914	2435000

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 75.02.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	75.02	gold quality
esophagus mucosa	UBERON:0002469	70.63	gold quality
omental fat pad	UBERON:0010414	66.62	gold quality
tibial artery	UBERON:0007610	65.52	gold quality
transverse colon	UBERON:0001157	64.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.51	gold quality
skin of abdomen	UBERON:0001416	62.75	gold quality
blood	UBERON:0000178	60.85	gold quality
cerebellar hemisphere	UBERON:0002245	52.68	gold quality
skin of leg	UBERON:0001511	41.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.