MIR711

Summary

MIR711 (microRNA 711, HGNC:37316) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313843 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37316
Approved symbol	MIR711
Name	microRNA 711
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-711
Ensembl gene	ENSG00000284251
Ensembl biotype	miRNA
Entrez	100313843
RNAcentral	URS000075B4E6 — miRNA, 76 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390201

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390201 — 1 exons

Exon	Start	End
ENSE00001507628	48578902	48578977

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 78.03.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.03	gold quality
gastrocnemius	UBERON:0001388	69.80	gold quality
islet of Langerhans	UBERON:0000006	69.79	gold quality
heart	UBERON:0000948	69.60	gold quality
endometrium	UBERON:0001295	69.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.29	gold quality
granulocyte	CL:0000094	66.74	gold quality
Ammon’s horn	UBERON:0001954	66.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.37	gold quality
tibial artery	UBERON:0007610	66.16	gold quality
heart left ventricle	UBERON:0002084	66.10	gold quality
skin of leg	UBERON:0001511	65.90	gold quality
zone of skin	UBERON:0000014	65.66	gold quality
skin of abdomen	UBERON:0001416	65.19	gold quality
anterior cingulate cortex	UBERON:0009835	64.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.67	gold quality
right frontal lobe	UBERON:0002810	64.29	gold quality
putamen	UBERON:0001874	64.28	gold quality
ectocervix	UBERON:0012249	64.21	gold quality
omental fat pad	UBERON:0010414	64.20	gold quality
ascending aorta	UBERON:0001496	64.11	gold quality
esophagus mucosa	UBERON:0002469	64.00	gold quality
transverse colon	UBERON:0001157	63.89	gold quality
thoracic aorta	UBERON:0001515	63.88	gold quality
left ovary	UBERON:0002119	63.67	gold quality
hypothalamus	UBERON:0001898	63.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.01	gold quality
vagina	UBERON:0000996	62.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Loss of miR711 is associated with gastric cancer. (PMID:26735582)
• These results illustrate an alternative mechanism of HIV-1 Vpr regulation of Kaposi’s sarcoma-associated herpesvirus (KSHV) latency and aberrant cytokines through the miR-711/Notch/NF-kappaB axis. Our novel findings further demonstrate the role of an HIV-1-secreted regulatory protein in the KSHV life cycle and KSHV-related malignancies. (PMID:29976660)
• we demonstrated that miR711mediated downregulation of CD44 expression inhibited EMT of gastric cancer cells in vitro and in vivo by downregulating vimentin protein expression and upregulating Ecadherin protein expression through transfection, qRTPCR and western blotting. (PMID:30226620)
• This study reveals that K562 cell-derived exosomal miR-711 can be transferred to bone marrow mesenchymal stem cells and weaken adhesive abilities by silencing the expression of the adhesion molecule CD44. (PMID:31677790)
• MiR-711 regulates gastric cancer progression by targeting CD44. (PMID:35786646)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir711	ENSMUSG00000076142
rattus_norvegicus	Mir711	ENSRNOG00000036531

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.