MIR7111

Summary

MIR7111 (microRNA 7111, HGNC:50073) is a microRNA gene on chromosome 6p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465668 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50073
Approved symbol	MIR7111
Name	microRNA 7111
Location	6p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7111
Ensembl gene	ENSG00000276712
Ensembl biotype	miRNA
Entrez	102465668
RNAcentral	URS000075EFAC — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619751

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619751 — 1 exons

Exon	Start	End
ENSE00003720803	35470508	35470579

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 95.25.

Top tissues by expression

220 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	95.25	gold quality
granulocyte	CL:0000094	94.24	gold quality
right uterine tube	UBERON:0001302	92.47	gold quality
mucosa of transverse colon	UBERON:0004991	88.22	gold quality
vermiform appendix	UBERON:0001154	87.64	gold quality
left ovary	UBERON:0002119	85.24	gold quality
ectocervix	UBERON:0012249	84.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.50	gold quality
right ovary	UBERON:0002118	84.18	gold quality
monocyte	CL:0000576	84.13	gold quality
vagina	UBERON:0000996	83.97	gold quality
adrenal tissue	UBERON:0018303	83.69	gold quality
buccal mucosa cell	CL:0002336	83.62	gold quality
body of uterus	UBERON:0009853	83.23	gold quality
esophagus mucosa	UBERON:0002469	82.97	gold quality
caecum	UBERON:0001153	82.81	gold quality
skin of abdomen	UBERON:0001416	82.30	gold quality
apex of heart	UBERON:0002098	81.41	gold quality
ovary	UBERON:0000992	80.93	gold quality
esophagus	UBERON:0001043	80.84	gold quality
kidney epithelium	UBERON:0004819	80.61	gold quality
uterine cervix	UBERON:0000002	80.56	gold quality
right atrium auricular region	UBERON:0006631	80.48	gold quality
omental fat pad	UBERON:0010414	80.10	gold quality
peritoneum	UBERON:0002358	80.07	gold quality
body of stomach	UBERON:0001161	80.02	gold quality
cardiac atrium	UBERON:0002081	80.00	gold quality
popliteal artery	UBERON:0002250	79.96	gold quality
tibial artery	UBERON:0007610	79.95	gold quality
transverse colon	UBERON:0001157	79.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.