MIR7112

Summary

MIR7112 (microRNA 7112, HGNC:50149) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465906 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50149
Approved symbol	MIR7112
Name	microRNA 7112
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7112-2, hsa-mir-7112-1
Ensembl gene	ENSG00000284054
Ensembl biotype	miRNA
Entrez	102465906
RNAcentral	URS000075A96C — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616126 — 1 exons

Exon	Start	End
ENSE00003716196	144262673	144262737

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 75.51.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	75.51	gold quality
blood	UBERON:0000178	74.99	gold quality
lymph node	UBERON:0000029	72.71	gold quality
gastrocnemius	UBERON:0001388	68.16	gold quality
substantia nigra	UBERON:0002038	68.05	gold quality
heart left ventricle	UBERON:0002084	66.97	gold quality
myometrium	UBERON:0001296	66.79	gold quality
right adrenal gland cortex	UBERON:0035827	65.83	gold quality
body of pancreas	UBERON:0001150	65.52	gold quality
skin of leg	UBERON:0001511	65.22	gold quality
thoracic aorta	UBERON:0001515	61.45	gold quality
body of stomach	UBERON:0001161	61.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.06	gold quality
hypothalamus	UBERON:0001898	60.53	gold quality
skin of abdomen	UBERON:0001416	58.25	gold quality
brain	UBERON:0000955	57.54	gold quality
upper lobe of left lung	UBERON:0008952	56.46	gold quality
tibial artery	UBERON:0007610	55.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.68	gold quality
omental fat pad	UBERON:0010414	53.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	51.69	gold quality
minor salivary gland	UBERON:0001830	50.68	gold quality
esophagus mucosa	UBERON:0002469	49.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	49.30	gold quality
nucleus accumbens	UBERON:0001882	48.88	gold quality
putamen	UBERON:0001874	42.50	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.