MIR7113

Summary

MIR7113 (microRNA 7113, HGNC:49947) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465669 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49947
Approved symbol	MIR7113
Name	microRNA 7113
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7113
Ensembl gene	ENSG00000284293
Ensembl biotype	miRNA
Entrez	102465669
RNAcentral	URS000075DBAA — ncRNA, 59 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621222

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621222 — 1 exons

Exon	Start	End
ENSE00003748624	68032864	68032922

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 75.77.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	75.77	gold quality
gastrocnemius	UBERON:0001388	72.76	gold quality
heart left ventricle	UBERON:0002084	71.39	gold quality
blood	UBERON:0000178	70.38	gold quality
tibial artery	UBERON:0007610	66.00	gold quality
skin of leg	UBERON:0001511	64.57	gold quality
body of pancreas	UBERON:0001150	64.13	gold quality
cerebellar hemisphere	UBERON:0002245	63.34	gold quality
right frontal lobe	UBERON:0002810	61.34	gold quality
skin of abdomen	UBERON:0001416	60.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.51	gold quality
esophagus mucosa	UBERON:0002469	59.30	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.20	gold quality
body of stomach	UBERON:0001161	58.96	gold quality
thoracic aorta	UBERON:0001515	56.05	gold quality
tibial nerve	UBERON:0001323	55.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	55.07	gold quality
omental fat pad	UBERON:0010414	54.50	gold quality
right atrium auricular region	UBERON:0006631	53.69	gold quality
ascending aorta	UBERON:0001496	53.54	gold quality
left lobe of thyroid gland	UBERON:0001120	52.55	gold quality
pituitary gland	UBERON:0000007	52.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	52.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	51.45	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.40	gold quality
minor salivary gland	UBERON:0001830	49.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	48.42	gold quality
thoracic mammary gland	UBERON:0005200	48.40	gold quality
transverse colon	UBERON:0001157	44.73	gold quality
hypothalamus	UBERON:0001898	44.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/beta-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype. (PMID:33189141)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.