MIR7114

Summary

MIR7114 (microRNA 7114, HGNC:50157) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466223 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50157
Approved symbol	MIR7114
Name	microRNA 7114
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7114
Ensembl gene	ENSG00000284317
Ensembl biotype	miRNA
Entrez	102466223
RNAcentral	URS0000759E40 — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611474

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611474 — 1 exons

Exon	Start	End
ENSE00003745161	137450026	137450086

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 74.24.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.24	gold quality
putamen	UBERON:0001874	72.26	gold quality
heart left ventricle	UBERON:0002084	68.77	gold quality
esophagus mucosa	UBERON:0002469	67.26	gold quality
body of stomach	UBERON:0001161	66.35	gold quality
prostate gland	UBERON:0002367	64.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.94	gold quality
body of uterus	UBERON:0009853	61.47	gold quality
skin of abdomen	UBERON:0001416	61.05	gold quality
skin of leg	UBERON:0001511	57.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.88	gold quality
thyroid gland	UBERON:0002046	55.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	54.42	gold quality
upper lobe of left lung	UBERON:0008952	54.08	gold quality
tibial nerve	UBERON:0001323	53.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.09	gold quality
vagina	UBERON:0000996	40.81	silver quality
omental fat pad	UBERON:0010414	37.42	silver quality
left testis	UBERON:0004533	29.33	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.