MIR7151

Summary

MIR7151 (microRNA 7151, HGNC:50170) is a microRNA gene on chromosome 10q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466814 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50170
Approved symbol	MIR7151
Name	microRNA 7151
Location	10q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7151
Ensembl gene	ENSG00000276866
Ensembl biotype	miRNA
Entrez	102466814
RNAcentral	URS000075A51E — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617477

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617477 — 1 exons

Exon	Start	End
ENSE00003734787	67403351	67403410

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 96.08.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.08	gold quality
corpus callosum	UBERON:0002336	89.78	gold quality
calcaneal tendon	UBERON:0003701	88.82	gold quality
adrenal tissue	UBERON:0018303	77.94	gold quality
heart	UBERON:0000948	75.98	gold quality
gastrocnemius	UBERON:0001388	75.73	gold quality
lung	UBERON:0002048	75.19	gold quality
stomach	UBERON:0000945	74.77	gold quality
blood	UBERON:0000178	73.04	gold quality
heart left ventricle	UBERON:0002084	72.17	gold quality
nucleus accumbens	UBERON:0001882	71.22	gold quality
tibial nerve	UBERON:0001323	70.31	gold quality
putamen	UBERON:0001874	69.07	gold quality
tibial artery	UBERON:0007610	68.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.02	gold quality
left coronary artery	UBERON:0001626	67.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.24	gold quality
caudate nucleus	UBERON:0001873	67.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.83	gold quality
intestine	UBERON:0000160	66.56	gold quality
right atrium auricular region	UBERON:0006631	66.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.38	gold quality
ascending aorta	UBERON:0001496	65.29	gold quality
substantia nigra	UBERON:0002038	65.19	gold quality
prostate gland	UBERON:0002367	64.94	gold quality
Ammon’s horn	UBERON:0001954	64.76	gold quality
esophagus mucosa	UBERON:0002469	64.40	gold quality
skin of leg	UBERON:0001511	64.25	gold quality
right frontal lobe	UBERON:0002810	64.06	gold quality
left lobe of thyroid gland	UBERON:0001120	63.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.