MIR7153

Summary

MIR7153 (microRNA 7153, HGNC:50190) is a microRNA gene on chromosome 18p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465690 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50190
Approved symbol	MIR7153
Name	microRNA 7153
Location	18p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7153
Ensembl gene	ENSG00000283492
Ensembl biotype	miRNA
Entrez	102465690
RNAcentral	URS000075AC82 — miRNA, 57 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637758

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637758 — 1 exons

Exon	Start	End
ENSE00003795105	11654885	11654941

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 95.59.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.59	gold quality
testis	UBERON:0000473	86.96	gold quality
left testis	UBERON:0004533	86.82	gold quality
right testis	UBERON:0004534	86.16	gold quality
blood	UBERON:0000178	78.31	gold quality
ovary	UBERON:0000992	76.34	gold quality
gastrocnemius	UBERON:0001388	75.39	gold quality
stomach	UBERON:0000945	74.65	gold quality
right atrium auricular region	UBERON:0006631	72.87	gold quality
monocyte	CL:0000576	72.27	gold quality
skin of abdomen	UBERON:0001416	70.94	gold quality
right lobe of liver	UBERON:0001114	69.48	gold quality
esophagus mucosa	UBERON:0002469	68.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.17	gold quality
brain	UBERON:0000955	68.08	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.34	gold quality
skin of leg	UBERON:0001511	64.65	gold quality
right frontal lobe	UBERON:0002810	62.60	gold quality
left lobe of thyroid gland	UBERON:0001120	61.94	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.