MIR7154

Summary

MIR7154 (microRNA 7154, HGNC:49972) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465691 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49972
Approved symbol	MIR7154
Name	microRNA 7154
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7154
Ensembl gene	ENSG00000276639
Ensembl biotype	miRNA
Entrez	102465691
RNAcentral	URS000075E270 — ncRNA, 73 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620673

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620673 — 1 exons

Exon	Start	End
ENSE00003721813	45691704	45691776

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 72.74.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	72.74	gold quality
gastrocnemius	UBERON:0001388	69.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.71	gold quality
omental fat pad	UBERON:0010414	63.58	gold quality
right frontal lobe	UBERON:0002810	60.50	gold quality
lung	UBERON:0002048	60.14	gold quality
testis	UBERON:0000473	54.54	gold quality
left testis	UBERON:0004533	51.66	gold quality
right testis	UBERON:0004534	49.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.