MIR7157

Summary

MIR7157 (microRNA 7157, HGNC:50010) is a microRNA gene on chromosome 2q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465692 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50010
Approved symbol	MIR7157
Name	microRNA 7157
Location	2q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7157
Ensembl gene	ENSG00000283506
Ensembl biotype	miRNA
Entrez	102465692
RNAcentral	URS000075A580 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635801

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635801 — 1 exons

Exon	Start	End
ENSE00003797718	140586626	140586685

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 79.58.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	79.58	gold quality
adrenal tissue	UBERON:0018303	75.49	gold quality
blood	UBERON:0000178	75.26	gold quality
intestine	UBERON:0000160	72.62	gold quality
transverse colon	UBERON:0001157	70.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.28	gold quality
amygdala	UBERON:0001876	70.17	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.28	gold quality
hypothalamus	UBERON:0001898	67.78	gold quality
skin of abdomen	UBERON:0001416	67.23	gold quality
skin of leg	UBERON:0001511	67.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.81	gold quality
corpus callosum	UBERON:0002336	65.88	gold quality
caudate nucleus	UBERON:0001873	65.33	gold quality
frontal cortex	UBERON:0001870	65.17	gold quality
nucleus accumbens	UBERON:0001882	64.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.67	gold quality
prostate gland	UBERON:0002367	64.07	gold quality
thyroid gland	UBERON:0002046	63.88	gold quality
cerebellar hemisphere	UBERON:0002245	63.66	gold quality
left lobe of thyroid gland	UBERON:0001120	63.58	gold quality
right frontal lobe	UBERON:0002810	63.45	gold quality
tibial nerve	UBERON:0001323	63.41	gold quality
pituitary gland	UBERON:0000007	62.50	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.35	gold quality
anterior cingulate cortex	UBERON:0009835	62.04	gold quality
vagina	UBERON:0000996	61.93	gold quality
right lobe of thyroid gland	UBERON:0001119	61.82	gold quality
body of uterus	UBERON:0009853	59.90	gold quality
left testis	UBERON:0004533	42.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.