MIR7158

Summary

MIR7158 (microRNA 7158, HGNC:49971) is a microRNA gene on chromosome 2p25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465693 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49971
Approved symbol	MIR7158
Name	microRNA 7158
Location	2p25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7158
Ensembl gene	ENSG00000276733
Ensembl biotype	miRNA
Entrez	102465693
RNAcentral	URS00007E36F1 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612300 — 1 exons

Exon	Start	End
ENSE00003726896	5974662	5974732

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 94.09.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	94.09	gold quality
prefrontal cortex	UBERON:0000451	87.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.62	gold quality
substantia nigra	UBERON:0002038	85.69	gold quality
Ammon’s horn	UBERON:0001954	83.63	gold quality
putamen	UBERON:0001874	82.32	gold quality
caudate nucleus	UBERON:0001873	81.21	gold quality
hypothalamus	UBERON:0001898	80.53	gold quality
amygdala	UBERON:0001876	80.15	gold quality
fundus of stomach	UBERON:0001160	79.52	gold quality
body of stomach	UBERON:0001161	78.60	gold quality
stomach	UBERON:0000945	78.57	gold quality
brain	UBERON:0000955	78.53	gold quality
cerebral cortex	UBERON:0000956	78.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.96	gold quality
frontal cortex	UBERON:0001870	77.95	gold quality
pituitary gland	UBERON:0000007	77.90	gold quality
nucleus accumbens	UBERON:0001882	77.40	gold quality
right frontal lobe	UBERON:0002810	77.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.35	gold quality
adrenal tissue	UBERON:0018303	75.89	gold quality
anterior cingulate cortex	UBERON:0009835	75.67	gold quality
monocyte	CL:0000576	75.43	gold quality
adenohypophysis	UBERON:0002196	73.69	gold quality
transverse colon	UBERON:0001157	72.60	gold quality
lung	UBERON:0002048	72.01	gold quality
heart left ventricle	UBERON:0002084	71.09	gold quality
heart	UBERON:0000948	70.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.05	gold quality
gastrocnemius	UBERON:0001388	69.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.