MIR7159

Summary

MIR7159 (microRNA 7159, HGNC:49978) is a microRNA gene on chromosome 6p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466816 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49978
Approved symbol	MIR7159
Name	microRNA 7159
Location	6p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7159
Ensembl gene	ENSG00000276824
Ensembl biotype	miRNA
Entrez	102466816
RNAcentral	URS000075C518 — ncRNA, 66 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620587

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620587 — 1 exons

Exon	Start	End
ENSE00003749265	33899135	33899200

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 75.89.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	75.89	gold quality
right frontal lobe	UBERON:0002810	71.82	gold quality
liver	UBERON:0002107	71.52	gold quality
blood	UBERON:0000178	70.43	gold quality
spleen	UBERON:0002106	70.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.13	gold quality
right testis	UBERON:0004534	63.38	gold quality
testis	UBERON:0000473	62.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.32	gold quality
left testis	UBERON:0004533	61.19	gold quality
skin of leg	UBERON:0001511	60.97	gold quality
cerebellar hemisphere	UBERON:0002245	60.92	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.37	gold quality
tibial nerve	UBERON:0001323	59.88	gold quality
corpus callosum	UBERON:0002336	44.26	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.