MIR7160

Summary

MIR7160 (microRNA 7160, HGNC:50028) is a microRNA gene on chromosome 8p23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465695 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50028
Approved symbol	MIR7160
Name	microRNA 7160
Location	8p23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7160
Ensembl gene	ENSG00000273593
Ensembl biotype	miRNA
Entrez	102465695
RNAcentral	URS000075E9F0 — miRNA, 52 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619295

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619295 — 1 exons

Exon	Start	End
ENSE00003743496	2076589	2076640

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 92.26.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	92.26	gold quality
skeletal muscle tissue	UBERON:0001134	88.99	gold quality
heart left ventricle	UBERON:0002084	83.29	gold quality
heart	UBERON:0000948	82.26	gold quality
right atrium auricular region	UBERON:0006631	80.16	gold quality
blood	UBERON:0000178	78.70	gold quality
monocyte	CL:0000576	77.50	gold quality
muscle of leg	UBERON:0001383	77.29	gold quality
gastrocnemius	UBERON:0001388	77.18	gold quality
stomach	UBERON:0000945	75.25	gold quality
body of pancreas	UBERON:0001150	75.14	gold quality
body of stomach	UBERON:0001161	73.85	gold quality
caudate nucleus	UBERON:0001873	72.90	gold quality
colon	UBERON:0001155	71.61	gold quality
tibial artery	UBERON:0007610	71.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.45	gold quality
transverse colon	UBERON:0001157	70.26	gold quality
left coronary artery	UBERON:0001626	70.25	gold quality
amygdala	UBERON:0001876	69.65	gold quality
intestine	UBERON:0000160	69.56	gold quality
right lobe of liver	UBERON:0001114	69.34	gold quality
lower esophagus	UBERON:0013473	68.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.68	gold quality
prostate gland	UBERON:0002367	68.14	gold quality
esophagus mucosa	UBERON:0002469	68.06	gold quality
anterior cingulate cortex	UBERON:0009835	67.93	gold quality
skin of leg	UBERON:0001511	67.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Silencing SIX1 by miR-7160 inhibits non-small cell lung cancer cell growth. (PMID:33686961)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.