MIR7161

Summary

MIR7161 (microRNA 7161, HGNC:49985) is a microRNA gene on chromosome 6q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465694 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49985
Approved symbol	MIR7161
Name	microRNA 7161
Location	6q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7161
Ensembl gene	ENSG00000278571
Ensembl biotype	miRNA
Entrez	102465694
RNAcentral	URS000075C8F6 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612973

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612973 — 1 exons

Exon	Start	End
ENSE00003740056	158609707	158609790

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 72.89.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	72.89	gold quality
right lobe of liver	UBERON:0001114	71.37	gold quality
islet of Langerhans	UBERON:0000006	69.48	gold quality
gastrocnemius	UBERON:0001388	68.22	gold quality
right adrenal gland cortex	UBERON:0035827	65.47	gold quality
leukocyte	CL:0000738	65.46	gold quality
body of pancreas	UBERON:0001150	65.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.04	gold quality
hypothalamus	UBERON:0001898	63.96	gold quality
left coronary artery	UBERON:0001626	63.88	gold quality
heart left ventricle	UBERON:0002084	63.82	gold quality
Ammon’s horn	UBERON:0001954	63.78	gold quality
putamen	UBERON:0001874	63.67	gold quality
caudate nucleus	UBERON:0001873	63.46	gold quality
endometrium	UBERON:0001295	63.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.20	gold quality
adrenal gland	UBERON:0002369	62.94	gold quality
blood	UBERON:0000178	62.80	gold quality
fallopian tube	UBERON:0003889	62.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.47	gold quality
ascending aorta	UBERON:0001496	62.45	gold quality
tibial artery	UBERON:0007610	62.45	gold quality
stomach	UBERON:0000945	62.17	gold quality
right atrium auricular region	UBERON:0006631	62.17	gold quality
esophagus mucosa	UBERON:0002469	61.38	gold quality
body of stomach	UBERON:0001161	61.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.33	gold quality
right frontal lobe	UBERON:0002810	60.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.