MIR718

Summary

MIR718 (microRNA 718, HGNC:37317) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313781 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37317
Approved symbol	MIR718
Name	microRNA 718
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-718
Ensembl gene	ENSG00000284286
Ensembl biotype	miRNA
OMIM	300929
Entrez	100313781
RNAcentral	URS000075EB45 — miRNA, 70 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390190 — 1 exons

Exon	Start	End
ENSE00001507617	154019920	154019989

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 78.97.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.97	gold quality
myometrium	UBERON:0001296	78.12	gold quality
blood	UBERON:0000178	76.19	gold quality
lung	UBERON:0002048	75.65	gold quality
gastrocnemius	UBERON:0001388	75.20	gold quality
caudate nucleus	UBERON:0001873	70.29	gold quality
right atrium auricular region	UBERON:0006631	70.11	gold quality
tibial artery	UBERON:0007610	69.65	gold quality
left adrenal gland cortex	UBERON:0035825	69.64	gold quality
adipose tissue	UBERON:0001013	69.36	gold quality
tibial nerve	UBERON:0001323	69.11	gold quality
upper lobe of left lung	UBERON:0008952	68.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.26	gold quality
skin of leg	UBERON:0001511	68.03	gold quality
left adrenal gland	UBERON:0001234	67.95	gold quality
colon	UBERON:0001155	67.83	gold quality
ascending aorta	UBERON:0001496	66.14	gold quality
left lobe of thyroid gland	UBERON:0001120	66.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.96	gold quality
omental fat pad	UBERON:0010414	65.61	gold quality
esophagus mucosa	UBERON:0002469	65.41	gold quality
right frontal lobe	UBERON:0002810	64.33	gold quality
skin of abdomen	UBERON:0001416	64.13	gold quality
left ovary	UBERON:0002119	63.88	gold quality
right ovary	UBERON:0002118	63.11	gold quality
transverse colon	UBERON:0001157	62.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.69	gold quality
pituitary gland	UBERON:0000007	61.28	gold quality
right lobe of liver	UBERON:0001114	60.86	gold quality
minor salivary gland	UBERON:0001830	60.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• the role of MiR-718 in the regulation of VEGF in ovarian cancer (PMID:24815691)
• this study identified HOXB8 as a potential target gene of miR-718, and its upregulation was associated with poor prognosis in hepatocellular carcinoma. (PMID:25584485)
• Plasma miRNA-718 is downregulated in ESCC patients and might serve as a potential diagnostic marker for ESCC. (PMID:26756617)
• miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC (PMID:28070994)
• We demonstrated that expression of PTEN and miR-718 were significantly correlated in patients with gastric cancer. Low expression of PTEN and high level of miR-718 were notably associated with a lower 5-year overall survival rate. Both PTEN and miR-718 were identified as prognostic factors of gastric cancer. (PMID:30131483)
• The present study strongly suggests that miR-718 inhibits papillary thyroid cancer cell proliferation, metastasis, and glucose metabolism…through PDPK1 (PMID:30166214)
• MiR-718 may mediate the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells. (PMID:31251699)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.