MIR7515

Summary

MIR7515 (microRNA 7515, HGNC:49839) is a microRNA gene on chromosome 2p25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466235 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49839
Approved symbol	MIR7515
Name	microRNA 7515
Location	2p25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-7515
Ensembl gene	ENSG00000283394
Ensembl biotype	miRNA
Entrez	102466235
RNAcentral	URS000075E5D4 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637837

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637837 — 1 exons

Exon	Start	End
ENSE00003800699	6650373	6650439

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 71.59.

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	71.59	gold quality
body of pancreas	UBERON:0001150	71.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miRNA7515 suppresses pancreatic cancer cell proliferation, migration and invasion via downregulating IGF1 expression. (PMID:34296285)
• microRNA-1321 and microRNA-7515 contribute to the progression of non-small cell lung cancer by targeting CDC20. (PMID:35050556)
• Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR. (PMID:37140169)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.