MIR758

Summary

MIR758 (microRNA 758, HGNC:33133) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768212 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33133
Approved symbol	MIR758
Name	microRNA 758
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-758
Ensembl gene	ENSG00000211582
Ensembl biotype	miRNA
Entrez	768212
RNAcentral	URS000075DEC1 — miRNA, 88 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390227

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390227 — 1 exons

Exon	Start	End
ENSE00001507654	101026020	101026107

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 94.85.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.85	gold quality
heart	UBERON:0000948	83.52	gold quality
stomach	UBERON:0000945	82.87	gold quality
lung	UBERON:0002048	81.64	gold quality
intestine	UBERON:0000160	79.70	gold quality
calcaneal tendon	UBERON:0003701	77.12	gold quality
monocyte	CL:0000576	76.42	gold quality
liver	UBERON:0002107	73.44	gold quality
myometrium	UBERON:0001296	72.58	gold quality
body of pancreas	UBERON:0001150	71.75	gold quality
blood	UBERON:0000178	71.52	gold quality
colon	UBERON:0001155	71.27	gold quality
vagina	UBERON:0000996	70.33	gold quality
tibial artery	UBERON:0007610	69.66	gold quality
ascending aorta	UBERON:0001496	69.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.65	gold quality
granulocyte	CL:0000094	68.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.34	gold quality
left adrenal gland	UBERON:0001234	67.71	gold quality
Ammon’s horn	UBERON:0001954	67.10	gold quality
transverse colon	UBERON:0001157	66.90	gold quality
corpus callosum	UBERON:0002336	66.75	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.16	gold quality
hypothalamus	UBERON:0001898	65.95	gold quality
adult mammalian kidney	UBERON:0000082	65.87	gold quality
skin of abdomen	UBERON:0001416	65.68	gold quality
body of stomach	UBERON:0001161	65.15	gold quality
nucleus accumbens	UBERON:0001882	65.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.70	gold quality
thoracic mammary gland	UBERON:0005200	64.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. (PMID:21885853)
• Hepatitis C virus infection decreases the expression of TLR-3 and TLR-7 via upregulation of miR-758. (PMID:25008898)
• MicroRNAs 758 and 33b are significantly upregulated in hypercholesterolemic plaques. (PMID:25445880)
• miR-758 is putative key regulators of Cholesterol-Efflux Regulatory Protein (ABCA1) within human atherosclerotic plaques. (PMID:26084456)
• Results suggest that microRNAs miR-221-5p, miR-380-3p, miR-556-5p, miR-758-3p and miR-3074-3p are potential diagnostic biomarkers of lupus nephritis in patients with systemic lupus erythematosus (SLE). (PMID:27835701)
• The present study concluded that miR-758-5p decreases lipid accumulation of foam cell via regulating CD36-mediated cholesterol uptake. (PMID:28965954)
• MiR-758-3p serves as a tumor suppressor and plays a crucial role in inhibiting the proliferation, migration and invasion of hepatocellular carcinoma cells. (PMID:29032337)
• This study provides evidence that, in HepG2 cells, GLP-1 may affect cholesterol homeostasis by regulating the expression of miR-758 and ABCA1. (PMID:29453982)
• DANCR promotes non-small cell lung cancer cell proliferation, migration and invasion by regulating the tumor suppressor miR-758-3p. (PMID:29635134)
• Data indicate that miR-758 is the direct target of long noncoding RNAs (lncRNAs) ANCR. (PMID:29913147)
• Low miR758 expression is associated with retinoblastoma. (PMID:30015924)
• The miR-758-5p overexpression inhibited the proliferation, migration, and invasion of glioblastoma cells and induced apoptosis by regulating the ZBTB20 expression. (PMID:30099442)
• miR-758 has lower expression in non-small cell lung cancer tissues.Mir-758 role in the non-small cell lung cancer proliferation, invasion and apoptosis.HMGB3 is the target gene of miR-758. (PMID:30446524)
• our study established a tumor-suppressive role for miR-758-3p in the inhibition of papillary thyroid cancer progression; MiR-758-3p regulates papillary thyroid cancer cell proliferation and migration by targeting TAB1 (PMID:30940308)
• lncRNA CASC9 sponges miR7583p to promote proliferation and EMT in bladder cancer by upregulating TGFbeta2. (PMID:33200222)
• [miR-758-3p inhibits the proliferation and invasion of non-small cell lung cancer cells by targeting NUSAP1]. (PMID:33472323)
• FAM201A knockdown inhibits proliferation and invasion of lung adenocarcinoma cells by regulating miR-7515/GLO1 axis. (PMID:33687075)
• Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis. (PMID:34081626)
• CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis. (PMID:35791460)
• Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer. (PMID:36356557)
• A study of differential microRNA expression profile in migraine: the microMIG exploratory study. (PMID:36797674)
• Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression. (PMID:37522575)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.