MIR759

Summary

MIR759 (microRNA 759, HGNC:37307) is a microRNA gene on chromosome 13q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313778 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37307
Approved symbol	MIR759
Name	microRNA 759
Location	13q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-759
Ensembl gene	ENSG00000211579
Ensembl biotype	miRNA
Entrez	100313778
RNAcentral	URS000075BF88 — miRNA, 91 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390224

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390224 — 1 exons

Exon	Start	End
ENSE00001507651	52810050	52810140

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 82.49.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.49	gold quality
corpus callosum	UBERON:0002336	77.38	gold quality
tibial artery	UBERON:0007610	69.51	gold quality
left lobe of thyroid gland	UBERON:0001120	65.73	gold quality
skin of leg	UBERON:0001511	65.03	gold quality
right frontal lobe	UBERON:0002810	65.01	gold quality
caudate nucleus	UBERON:0001873	64.57	gold quality
putamen	UBERON:0001874	64.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.27	gold quality
substantia nigra	UBERON:0002038	62.58	gold quality
transverse colon	UBERON:0001157	61.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.55	gold quality
hypothalamus	UBERON:0001898	58.01	gold quality
left ovary	UBERON:0002119	56.98	gold quality
nucleus accumbens	UBERON:0001882	56.47	gold quality
colon	UBERON:0001155	54.58	gold quality
left testis	UBERON:0004533	40.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data suggest that the expression of FGA was regulated by miR-759 through its interaction at the polymorphic 3’UTR sequence, which was associated with the susceptibility to CTEPH. (PMID:20677013)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.