MIR760

Summary

MIR760 (microRNA 760, HGNC:33666) is a microRNA gene on chromosome 1p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126348 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33666
Approved symbol	MIR760
Name	microRNA 760
Location	1p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-760
Ensembl gene	ENSG00000211575
Ensembl biotype	miRNA
Entrez	100126348
RNAcentral	URS000075ABEC — miRNA, 80 nt, 27 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390220

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390220 — 1 exons

Exon	Start	End
ENSE00001507647	93846832	93846911

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 93.32.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2629 / max 31.6045, expressed in 449 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4077	1.2629	449

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.32	gold quality
adrenal tissue	UBERON:0018303	82.16	gold quality
bone marrow	UBERON:0002371	81.47	gold quality
vermiform appendix	UBERON:0001154	81.23	gold quality
prefrontal cortex	UBERON:0000451	80.40	gold quality
blood	UBERON:0000178	78.88	gold quality
calcaneal tendon	UBERON:0003701	78.10	gold quality
monocyte	CL:0000576	76.14	gold quality
muscle of leg	UBERON:0001383	74.63	gold quality
placenta	UBERON:0001987	74.14	gold quality
gastrocnemius	UBERON:0001388	73.33	gold quality
endometrium	UBERON:0001295	72.39	gold quality
islet of Langerhans	UBERON:0000006	72.02	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.82	gold quality
ectocervix	UBERON:0012249	69.46	gold quality
adult mammalian kidney	UBERON:0000082	69.44	gold quality
anterior cingulate cortex	UBERON:0009835	69.39	gold quality
Ammon’s horn	UBERON:0001954	69.24	gold quality
cerebral cortex	UBERON:0000956	69.23	gold quality
cerebellar hemisphere	UBERON:0002245	69.23	gold quality
heart left ventricle	UBERON:0002084	69.14	gold quality
right coronary artery	UBERON:0001625	69.11	gold quality
stomach	UBERON:0000945	68.92	gold quality
smooth muscle tissue	UBERON:0001135	68.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.74	gold quality
heart	UBERON:0000948	68.65	gold quality
body of pancreas	UBERON:0001150	68.44	gold quality
caudate nucleus	UBERON:0001873	68.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 32)

• Plasma miR-601 and miR-760 can potentially serve as promising non-invasive biomarkers for the early detection of colorectal cancer. (PMID:22970209)
• miR-760 is downregulated in the bone marrow and primary tumor of stage IV patients compared with stage I patients. (PMID:24097871)
• Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells. (PMID:25139266)
• The expression pattern of miR-760 targeted mRNAs and their potential functions and participated-pathways in breast cancer drug resistance cells, were determined. (PMID:25661353)
• miR-760 was proved to be functional associated with NANOG via regulating its expression. (PMID:27133070)
• Expression of miR-760 was markedly upregulated in ovarian cancer cell lines and tissues. Mir-760 overexpression downregulates PHLPP2 expression, promoting proliferation. (PMID:27726922)
• In conclusion, serum level of miR-92a, miR-375, and miR-760 may serve as biomarkers of colorectal cancer in Egyptian patients with high diagnostic power for miR-760 and high prognostic power for miR-92a (PMID:28618945)
• Expression of miR-760 was downregulated in NSCLC tissues compared with the adjacent normal tissues and NSCLC cell lines. (PMID:29372517)
• miR-760 should be considered as a tumor suppressor since it negatively regulates the oncogene protein FOXA1 and regulated TRAIL sensitivity in Non-small cell lung cancer cells. (PMID:29665655)
• results demonstrate that miR-760 inhibits Dox-resistance in HCC cells through inhibiting Notch1 and promoting PTEN expression (PMID:29968951)
• Long non-coding RNA LOC730100 is a competing endogenous RNA for miR-760 and promotes FOXA1 expression. miR-760 suppresses glioma progression by targeting FOXA1. (PMID:30914197)
• MicroRNA-760 inhibits the biological progression of colorectal carcinoma by directly targeting FOXA1 and regulating epithelial-to-mesenchymal transition and PI3K/AKT signaling pathway. (PMID:31298352)
• Overexpression of IL22RA1 enhanced HTFs migration and proliferation, while miR-760 and miR-215-3p mimics reversed these promotive biological roles induced by IL22RA1. In conclusion, NR_003923 and IL22RA1 might contribute to glaucoma progression and be a novel and potential biomarkers and therapeutic targets for glaucoma (PMID:31391457)
• MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin beta1. (PMID:31693728)
• miR-760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c-Myc. (PMID:31709636)
• mir760 targets GIT1 to inhibit cell growth and promote apoptosis in gastric cancer cells (PMID:31832002)
• SOX2-induced upregulation of lncRNA LINC01561 promotes non-small-cell lung carcinoma progression by sponging miR-760 to modulate SHCBP1 expression. (PMID:32003010)
• NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760. (PMID:32091103)
• MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer. (PMID:32167539)
• Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis. (PMID:32196590)
• the role of miR-760 in the progression of different cancer, is reviewed. (PMID:32251703)
• Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6. (PMID:32415054)
• circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. (PMID:32540374)
• miR760 regulates ATXN1 levels via interaction with its 5’ untranslated region. (PMID:32763910)
• PVT1 induces NSCLC cell migration and invasion by regulating IL-6 via sponging miR-760. (PMID:32866660)
• miR-760 mediated the proliferation and metastasis of hepatocellular carcinoma cells by regulating HMGA2. (PMID:33887625)
• LncRNA LINC00963 promotes osteogenic differentiation of hBMSCs and alleviates osteoporosis progression by targeting miRNA-760/ETS1 axis. (PMID:34184952)
• Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis. (PMID:34310809)
• Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction. (PMID:35163809)
• Mechanism of miR-760 Reversing Lung Cancer Immune Escape by Downregulating IDO1 and Eliminating Regulatory T Cells Based on Mathematical Biology. (PMID:35872931)
• Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway. (PMID:36153332)
• Identification of miR-106b-5p, miR-601, and miR-760 Expression and Their Clinical Values in Non-Small Cell Lung Cancer (NSCLC) Patients’ Serum. (PMID:37429174)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.