MIR761

Summary

MIR761 (microRNA 761, HGNC:37305) is a microRNA gene on chromosome 1p32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313892 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37305
Approved symbol	MIR761
Name	microRNA 761
Location	1p32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-761
Ensembl gene	ENSG00000283899
Ensembl biotype	miRNA
Entrez	100313892
RNAcentral	URS000075F0EC — miRNA, 59 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390787

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390787 — 1 exons

Exon	Start	End
ENSE00001508464	51836344	51836402

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 77.32.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.45	gold quality
gastrocnemius	UBERON:0001388	73.99	gold quality
endometrium	UBERON:0001295	73.38	gold quality
left adrenal gland cortex	UBERON:0035825	71.65	gold quality
body of pancreas	UBERON:0001150	70.66	gold quality
omental fat pad	UBERON:0010414	69.81	gold quality
popliteal artery	UBERON:0002250	68.81	gold quality
tibial artery	UBERON:0007610	68.71	gold quality
ascending aorta	UBERON:0001496	67.93	gold quality
skin of leg	UBERON:0001511	67.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.53	gold quality
left coronary artery	UBERON:0001626	67.33	gold quality
body of stomach	UBERON:0001161	67.18	gold quality
thoracic mammary gland	UBERON:0005200	67.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.96	gold quality
intestine	UBERON:0000160	66.86	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.51	gold quality
colon	UBERON:0001155	66.15	gold quality
myometrium	UBERON:0001296	65.99	gold quality
minor salivary gland	UBERON:0001830	65.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.57	gold quality
body of uterus	UBERON:0009853	65.56	gold quality
spleen	UBERON:0002106	65.21	gold quality
skin of abdomen	UBERON:0001416	65.07	gold quality
right frontal lobe	UBERON:0002810	64.96	gold quality
right lobe of thyroid gland	UBERON:0001119	64.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.89	gold quality
nucleus accumbens	UBERON:0001882	63.80	gold quality
anterior cingulate cortex	UBERON:0009835	63.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• miR-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR-761 repressed ovarian cancer proliferation and invasion by targeting MSI1 (PMID:26563371)
• Our findings provide new insight into the mechanism underlying Mitofusin-2 regulation and the potential role of miR-761 in tocellular carcinoma, making it a potential candidate for use in HCC therapy in the future (PMID:26845057)
• miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. (PMID:28054302)
• Our findings provide new insight into the potential role of miR-761, an EV-secreted miRNA from synovial sarcoma cells, making it a potential candidate for use in sarcoma therapy in the future. (PMID:29191657)
• hsa_circ_0007534 serves as an oncogene in glioma via promoting ZIC5 expression by repressing miR-761 availability. (PMID:29605301)
• Over-expression of FENDRR inhibited the malignant phenotypes of non-small cell lung carcinoma cells by binding competitively to miR-761. (PMID:30556873)
• HDAC1 expression could be regulated and was negatively correlated with miR-761 in CRC. Authors also indicated that the expression of miR-761 was abnormally downregulated in CRC. Transfection with a miR-761 mimic impeded the growth and invasion of CRC cells. (PMID:30782261)
• LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway. (PMID:31298329)
• long noncoding RNA FENDRR suppressed the progression of non-small cell lung cancer via binding to miR-761 and regulating TIMP2 expression. (PMID:31545237)
• Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. (PMID:32196629)
• MicroRNA-761 modulates foam cell formation and inflammation through autophagy in the progression of atherosclerosis. (PMID:32772311)
• Long Noncoding RNA KCNQ1OT1 Confers Gliomas Resistance to Temozolomide and Enhances Cell Growth by Retrieving PIM1 From miR-761. (PMID:32897512)
• MicroRNA-761 suppresses tumor progression in osteosarcoma via negatively regulating ALDH1B1. (PMID:33035586)
• Knockdown of lncRNA PVT1 inhibits the proliferation and accelerates the apoptosis of colorectal cancer cells via the miR761/MAPK1 axis. (PMID:34515320)
• CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer. (PMID:34922544)
• Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761. (PMID:35030964)
• Exosomal lncRNA HOTAIR Promotes the Progression and Angiogenesis of Endometriosis via the miR-761/HDAC1 Axis and Activation of STAT3-Mediated Inflammation. (PMID:35321026)
• Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling. (PMID:36056285)
• circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. (PMID:36278814)
• Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions. (PMID:37258120)
• The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis. (PMID:38960059)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir761	ENSMUSG00000076444
rattus_norvegicus	Mir761	ENSRNOG00000040424

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.